Guayacán is the Spanish word for species in the genus Guaiacum.
Guayacán may also refer to:
- Albizia pistaciifolia, Guayacán Cenega, Guayacán Chaparro or Guayacán Hobo (Colombia)
- Centrolobium yavizanum (Colombia)
- Minquartia guianensis (Ecuador)
- Porlieria chilensis (Chile)
- Tabebuia chrysantha (Ecuador, Venezuela)
- Guayacán, a novel by Guatemalan writer Virgilio Rodríguez Macal