Guggenheim is a surname. Notable people with the name include:
- Guggenheim family, American family of Swiss Jewish ancestry
- Meyer Guggenheim (1828–1905)
- Daniel Guggenheim (1856–1930)
- Harry Frank Guggenheim who privately funded Goddard's liquid fuel rocket research (1890–1971)
- Solomon R. Guggenheim (1861–1949), philanthropist who established the Guggenheim museum
- Benjamin Guggenheim (1865–1912)
- Peggy Guggenheim (1898–1979)
- Simon Guggenheim (1867–1941)
- Daniel Guggenheim (1856–1930)
- Meyer Guggenheim (1828–1905)
- Charles Guggenheim (1924–2002), American Academy Award-winning documentary film maker
- Davis Guggenheim (born 1963), American Academy Award-winning documentary film maker
- Edward A. Guggenheim (1901–1970), English chemist and academic noted for chemical thermodynamics
- Marc Guggenheim (born 1970), American screenwriter
- Paul Guggenheim (1899–1977), Swiss scholar of international law
- Ralph Guggenheim (born 1951), American video graphics designer and businessman