Gunda Köllensperger is an Austrian chemist and professor of chemistry at the University of Vienna. She investigates metallobiomolecules and drugs using inductively coupled plasma mass spectrometry. She was awarded the 2023 Houska Prize for her prize in Analytical Chemistry.
Gunda Köllensperger | |
|---|---|
| Alma mater | Technical University of Vienna |
| Scientific career | |
| Institutions | University of Natural Resources and Life Sciences, Vienna Humboldt University |
| Thesis | Investigation of small particles by scanning force microscopy (1998) |
| Website | Köellensperger Lab |
Early life and education
editKöllensperger was an undergraduate student at the Technical University of Vienna where she used laser-based approaches for mass spectrometry. She remained there as a doctoral student, where she studied small particles using scanning force microscopy.[1]
Research and career
editKöllensperger joined the University of Natural Resources and Life Sciences, BOKU, as an assistant professor. She completed her habilitation in analytical chemistry on inductively coupled plasma mass spectrometry. She was promoted to associate professor in 2003. In 2011 she moved to the Austrian Centre for Industrial Biotechnology, where she led the facility in metabolomics. In 2014 Köllensperger was made Professor of Environmental Chemistry at the University of Vienna. She was made Head of the Institute of Analytical Chemistry in 2016.[2]
Köllensperger works alongside the Medical University of Vienna to improve the diagnosis and treatment of cancer patients. Metal-based chemotherapies offer routes to precise and targeted cancer therapies, but do not always achieve positive outcomes and can result in side effects.[3] She is interested in the fate and impact of platinum-based compounds and the identification of strategies to manipulate the tumour environment. Anticancer platinum-based compounds have traditionally caused damage because they are toxic to healthy human tissue. Köllensperger and co-workers showed that it would be possible to attach two moieties to direct the compounds to the malignant tissue. These anticancer drugs bind to the blood protein albumin, which is degraded by the tumour but less by health cells, and release in the malignant tissues beside cytotoxic chemotherapy.[3]
She developed U13C-isotopically labelled biomass extracts as a standardisation tool for metabolomics. The integration of isotopically enriched biomass was shown to increase analytical throughput.[4]
Awards and honours
edit- 2001 BOKU Preis der Wiener Wirtschaftskammer[5]
- 2010 Austrian Society of Analytical Chemistry Fritz Feigl Award
- 2015 Fellinger Krebsforschung Award
- 2016 Fonds der Stadt Wien für innovative interdisziplinäre Krebsforschung Award[6]
- Prize Lipidome Isotope Labeling of Yeast[7]
- 2023 Houska Prize[8]
- 2024 Analytical Scientist Power List - Instrumental Innovators[9]
Select publications
edit- Carlos Guijas; J. Rafael Montenegro-Burke; Xavier Domingo-Almenara; et al. (9 February 2018). "METLIN: A Technology Platform for Identifying Knowns and Unknowns". Analytical Chemistry. 90 (5): 3156–3164. doi:10.1021/ACS.ANALCHEM.7B04424. ISSN 0003-2700. PMC 5933435. PMID 29381867. Wikidata Q47554803.
- Walter J Fitz; Walter W Wenzel; Hao Zhang; et al. (1 November 2003). "Rhizosphere characteristics of the arsenic hyperaccumulator Pteris vittata L. and monitoring of phytoremoval efficiency". Environmental Science & Technology. 37 (21): 5008–5014. doi:10.1021/ES0300214. ISSN 0013-936X. PMID 14620831. Wikidata Q79298582.
- Petra Heffeter; Katharina Böck; Bihter Atil; et al. (11 March 2010). "Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339". Journal of Biological Inorganic Chemistry. 15 (5): 737–748. doi:10.1007/S00775-010-0642-1. ISSN 0949-8257. PMC 3371400. PMID 20221888. Wikidata Q42040747.
References
edit- ^ "CV Köllensperger". koellenspergerlab.univie.ac.at. Retrieved 2024-01-26.
- ^ "Gunda Köllensperger". ewcps2017.at. Retrieved 2024-01-26.
- ^ a b Vienna, Medical University of. "The tumor microenvironment as target and regulator of anticancer (metal) drug response | MedUni Vienna". Medical University of Vienna. Retrieved 2024-01-26.
- ^ "Harnessing the Power of Isotopically Labelled Biomass for Accurate Quantitative Analysis". Chromatography Online. 2023-06-20. Retrieved 2024-01-26.
- ^ "Researcher/Gunda Köllensperger". forschung.boku.ac.at. Retrieved 2024-05-28.
- ^ ktv_tkiebl. "Wiener Stiftungs- und Fondsregister - Fonds der Stadt Wien für innovative interdisziplinäre Krebsforschung". www.wien.gv.at (in German). Retrieved 2024-01-26.
- ^ "Forschung". wochem.univie.ac.at (in German). Retrieved 2024-01-26.
- ^ "B&C-Gruppe Podcast: The Houska Prize". B&C Gruppe. Retrieved 2024-01-26.
- ^ "The Power List 2024". The Analytical Scientist. 2024-08-17. Retrieved 2024-08-24.