Histone H1oo is a protein that in humans is encoded by the H1FOO gene.[5][6]

H1-8
Identifiers
AliasesH1-8, osH1, H1.8, H1oo, H1 histone family member O, oocyte specific, H1 histone family member O oocyte specific, H1.8 linker histone, H1FOO
External IDsMGI: 2176207; HomoloGene: 51377; GeneCards: H1-8; OMA:H1-8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308262
NM_153833

NM_138311
NM_001346702

RefSeq (protein)

NP_001295191
NP_722575

NP_001333631
NP_612184

Location (UCSC)Chr 3: 129.54 – 129.55 MbChr 6: 115.92 – 115.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.[6]

It incorporates into sperm chromatin after fertilisation.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178804Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042279Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. ^ a b "Entrez Gene: H1 histone family".
  7. ^ Mizusawa Y, Kuji N, Tanaka Y, et al. (March 2010). "Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization". Fertil Steril. 93 (4): 1134–1141. doi:10.1016/j.fertnstert.2008.11.028. PMID 19147139.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.