H1 histone family, member N, testis-specific is a member of the histone family of nuclear proteins which are a component of chromatin. In humans, this protein is encoded by the H1FNT gene.[1]
| H1 histone family, member N, testis-specific | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | H1FNT | ||||||
| Alt. symbols | HANP1, H1T2 | ||||||
| NCBI gene | 341567 | ||||||
| HGNC | 24893 | ||||||
| RefSeq | NM_181788 | ||||||
| UniProt | Q75WM6 | ||||||
| Other data | |||||||
| Locus | Chr. 12 q13.11 | ||||||
| |||||||
The H1FNT protein is essential for nuclear formation in spermatozoa, and is involved in the replacement of histones with protamines during spermiogenesis.[2]
References
edit- ^ Martianov I, Brancorsini S, Catena R, et al. (February 2005). "Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 102 (8): 2808–13. Bibcode:2005PNAS..102.2808M. doi:10.1073/pnas.0406060102. PMC 549447. PMID 15710904.
- ^ Tanaka H, Matsuoka Y, Onishi M, Kitamura K, Miyagawa Y, Nishimura H, Tsujimura A, Okuyama A, Nishimune Y (April 2006). "Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein". International Journal of Andrology. 29 (2): 353–9. doi:10.1111/j.1365-2605.2005.00600.x. PMID 16533358.
External links
edit- H1FNT+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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