H2AFB3

H2A histone family, member B3 is a protein that in humans is encoded by the H2AFB3 gene.

H2AB3
Identifiers
Aliases	H2AB3, H2ABBD, H2AFB, H2A histone family member B3, H2A.B variant histone 3, H2AFB3, H2AB2, H2A.B.1
External IDs	OMIM: 300445; MGI: 3644980; HomoloGene: 129517; GeneCards: H2AB3; OMA:H2AB3 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 155,459,415 bp End 155,460,005 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X E1 Start 115,590,875 bp End 115,591,222 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad right coronary artery right testis right ovary left uterine tube spleen blood gastric mucosa canal of the cervix duodenum Top expressed in spleen thymus dentate gyrus of hippocampal formation granule cell lung More reference expression data BioGPS n/a
Gene ontology Molecular function protein heterodimerization activity DNA binding Cellular component nucleosome nucleus chromosome Biological process nucleosome assembly mRNA processing chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83740 624153 Ensembl ENSG00000277745 ENSMUSG00000082482 UniProt P0C5Z0 S4R1M3 RefSeq (mRNA) NM_080720 NM_001281530 RefSeq (protein) NP_001017991 NP_001268459 Location (UCSC) Chr X: 155.46 – 155.46 Mb Chr X: 115.59 – 115.59 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most telomeric copy. [provided by RefSeq, Jul 2008].

Further reading

• Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F (November 2000). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
• Chadwick BP, Willard HF (January 2001). "A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome". The Journal of Cell Biology. 152 (2): 375–84. doi:10.1083/jcb.152.2.375. PMC 2199617. PMID 11266453.
• Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F (October 2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
• Lusic M, Marcello A, Cereseto A, Giacca M (December 2003). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". The EMBO Journal. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Bao Y, Konesky K, Park YJ, Rosu S, Dyer PN, Rangasamy D, Tremethick DJ, Laybourn PJ, Luger K (August 2004). "Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA". The EMBO Journal. 23 (16): 3314–24. doi:10.1038/sj.emboj.7600316. PMC 514500. PMID 15257289.
• Okuwaki M, Kato K, Shimahara H, Tate S, Nagata K (December 2005). "Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I". Molecular and Cellular Biology. 25 (23): 10639–51. doi:10.1128/MCB.25.23.10639-10651.2005. PMC 1291234. PMID 16287874.
• Naylor JA, Buck D, Green P, Williamson H, Bentley D, Giannelli F (July 1995). "Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions". Human Molecular Genetics. 4 (7): 1217–24. doi:10.1093/hmg/4.7.1217. PMID 8528212.
• El Kharroubi A, Piras G, Zensen R, Martin MA (May 1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Molecular and Cellular Biology. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.