Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene .[ 5] [ 6]
Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000086506 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073063 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster" . Blood . 73 (5): 1081–104. doi :10.1182/blood.V73.5.1081.1081 PMID 2649166 . ^ a b "Entrez Gene: HBQ1 hemoglobin, theta 1" .
Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Crit. Rev. Biochem. Mol. Biol . 30 (3): 165–96. doi :10.3109/10409239509085142 . PMID 7555018 . Kim JH, Yu CY, Bailey A, et al. (1989). "Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters" . Nucleic Acids Res . 17 (14): 5687–700. doi :10.1093/nar/17.14.5687 . PMC 318189 PMID 2569721 . Ley TJ, Maloney KA, Gordon JI, Schwartz AL (1989). "Globin gene expression in erythroid human fetal liver cells" . J. Clin. Invest . 83 (3): 1032–8. doi :10.1172/JCI113944 . PMC 303780 PMID 2921315 . Gonzalez-Redondo JM, Han IS, Gu YC, Huisman TH (1988). "Nucleotide sequence of the human theta 1-globin gene". Biochem. Genet . 26 (3–4): 207–11. doi :10.1007/BF00561460 . PMID 3408475 . S2CID 19352648 . Hsu SL, Marks J, Shaw JP, et al. (1988). "Structure and expression of the human theta 1 globin gene". Nature . 331 (6151): 94–6. Bibcode :1988Natur.331...94H . doi :10.1038/331094a0 . PMID 3422341 . S2CID 4357357 . Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16" . Hum. Mol. Genet . 10 (4): 339–52. doi :10.1093/hmg/10.4.339 PMID 11157797 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . De Gobbi M, Viprakasit V, Hughes JR, et al. (2006). "A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter". Science . 312 (5777): 1215–7. Bibcode :2006Sci...312.1215D . doi :10.1126/science.1126431 . PMID 16728641 . S2CID 16044469 .
