Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.[4][5][6]

HCLS1
Identifiers
AliasesHCLS1, CTTNL, HS1, lckBP1, p75, hematopoietic cell-specific Lyn substrate 1
External IDsOMIM: 601306; MGI: 104568; HomoloGene: 38034; GeneCards: HCLS1; OMA:HCLS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005335
NM_001292041

NM_008225

RefSeq (protein)

NP_001278970
NP_005326

NP_032251

Location (UCSC)n/aChr 16: 36.76 – 36.78 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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HCLS1 has been shown to interact with Caspase 3.[7][8]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022831Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Egashira M, Kitamura D, Watanabe T, Niikawa N (Jan 1997). "The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 175–6. doi:10.1159/000134179. PMID 8978766.
  5. ^ van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E (Mar 2005). "Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain". BMC Genomics. 6: 15. doi:10.1186/1471-2164-6-15. PMC 554100. PMID 15710041.
  6. ^ "Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1".
  7. ^ Ruzzene, Maria; Penzo Daniele; Pinna Lorenzo A (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. 364 (Pt 1). England: 41–7. doi:10.1042/bj3640041. ISSN 0264-6021. PMC 1222543. PMID 11988074.
  8. ^ Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. 288 (4). United States: 981–9. doi:10.1006/bbrc.2001.5862. ISSN 0006-291X. PMID 11689006.

Further reading

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