Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCST gene.[5][6]

HCST
Identifiers
AliasesHCST, DAP10, KAP10, PIK3AP, hematopoietic cell signal transducer
External IDsOMIM: 604089; MGI: 1344360; HomoloGene: 8024; GeneCards: HCST; OMA:HCST - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014266
NM_001007469

NM_011827

RefSeq (protein)

NP_001007470
NP_055081

NP_035957

Location (UCSC)Chr 19: 35.9 – 35.9 MbChr 7: 30.12 – 30.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126264Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064109Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH (Aug 1999). "An activating immunoreceptor complex formed by NKG2D and DAP10". Science. 285 (5428): 730–2. doi:10.1126/science.285.5428.730. PMID 10426994.
  6. ^ a b "Entrez Gene: HCST hematopoietic cell signal transducer".

Further reading

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