HDLBP

Vigilin is a 110 kDa protein that in humans is encoded by the HDLBP gene.

HDLBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VIG, 1VIH, 2CTE, 2CTF, 2CTJ, 2CTK, 2CTL, 2CTM
Identifiers
Aliases	HDLBP, HBP, PRO2900, VGL, high density lipoprotein binding protein
External IDs	OMIM: 142695; MGI: 99256; HomoloGene: 38035; GeneCards: HDLBP; OMA:HDLBP - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.3 Start 241,227,264 bp End 241,317,061 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 D|1 47.24 cM Start 93,333,662 bp End 93,406,537 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium body of pancreas Achilles tendon anterior pituitary left testis epithelium of colon right testis right lobe of thyroid gland muscle of thigh body of stomach Top expressed in tail of embryo lacrimal gland genital tubercle calvaria salivary gland parotid gland molar muscle of thigh gastrula ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding nucleic acid binding RNA binding cadherin binding Cellular component plasma membrane nucleus high-density lipoprotein particle cytoplasm cytosol Biological process lipid metabolism steroid metabolic process lipid transport cholesterol metabolic process high-density lipoprotein particle clearance transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3069 110611 Ensembl ENSG00000115677 ENSMUSG00000034088 UniProt Q00341 Q8VDJ3 RefSeq (mRNA) NM_001243900 NM_005336 NM_203346 NM_001320965 NM_001320966 NM_001320967 NM_001301364 NM_133808 NM_001357556 RefSeq (protein) NP_001230829 NP_001307894 NP_001307895 NP_001307896 NP_005327 NP_976221 NP_001288293 NP_598569 NP_001344485 Location (UCSC) Chr 2: 241.23 – 241.32 Mb Chr 1: 93.33 – 93.41 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects". Mol. Cell. Proteomics. 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
• Graham DL, Oram JF (1987). "Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting". J. Biol. Chem. 262 (16): 7439–42. doi:10.1016/S0021-9258(18)47584-9. PMID 3034894.
• Plenz G, Kügler S, Schnittger S, et al. (1994). "The human vigilin gene: identification, chromosomal localization and expression pattern". Hum. Genet. 93 (5): 575–82. doi:10.1007/BF00202827. PMID 8168838. S2CID 25536273.
• Neu-Yilik G, Zorbas H, Gloe TR, et al. (1993). "Vigilin is a cytoplasmic protein. A study on its expression in primary cells and in established cell lines of different species". Eur. J. Biochem. 213 (2): 727–36. doi:10.1111/j.1432-1033.1993.tb17813.x. PMID 8477745.
• Kügler S, Grünweller A, Probst C, et al. (1996). "Vigilin contains a functional nuclear localisation sequence and is present in both the cytoplasm and the nucleus". FEBS Lett. 382 (3): 330–4. doi:10.1016/0014-5793(96)00204-9. PMID 8605996. S2CID 42740112.
• Kügler S, Plenz G, Müller PK (1996). "Two additional 5' exons in the human Vigilin gene distinguish it from the chicken gene and provide the structural basis for differential routes of gene expression". Eur. J. Biochem. 238 (2): 410–7. doi:10.1111/j.1432-1033.1996.0410z.x. PMID 8681952.
• Chiu DS, Oram JF, LeBoeuf RC, et al. (1998). "High-density lipoprotein-binding protein (HBP)/vigilin is expressed in human atherosclerotic lesions and colocalizes with apolipoprotein E." Arterioscler. Thromb. Vasc. Biol. 17 (11): 2350–8. doi:10.1161/01.ATV.17.11.2350. PMID 9409201.
• Kruse C, Willkomm DK, Grünweller A, et al. (2000). "Export and transport of tRNA are coupled to a multi-protein complex". Biochem. J. 346 (Pt 1): 107–15. doi:10.1042/0264-6021:3460107. PMC 1220829. PMID 10657246.
• Bocharov AV, Vishnyakova TG, Baranova IN, et al. (2001). "Characterization of a 95 kDa high affinity human high density lipoprotein-binding protein". Biochemistry. 40 (14): 4407–16. doi:10.1021/bi001503k. PMID 11284697.
• Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell. Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
• Goolsby KM, Shapiro DJ (2003). "RNAi-mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non-dividing human cells but does not initially inhibit protein synthesis". Nucleic Acids Res. 31 (19): 5644–53. doi:10.1093/nar/gkg768. PMC 206468. PMID 14500828.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Vollbrandt T, Willkomm D, Stossberg H, Kruse C (2004). "Vigilin is co-localized with 80S ribosomes and binds to the ribosomal complex through its C-terminal domain". Int. J. Biochem. Cell Biol. 36 (7): 1306–18. doi:10.1016/j.biocel.2003.11.006. PMID 15109574.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.