Probable E3 ubiquitin-protein ligase HERC3 is an enzyme that in humans is encoded by the HERC3 gene.[1][2] The gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and an RCC1-like domain (RLD). It binds ubiquitin and hPLIC-1/2 via its HECT domain. Alternatively spiced transcript variants encoding multiple isoforms have been observed, and mutations in this gene have been linked to colorectal and gastric carcinomas. The protein is localized in the cytosol and vesicular-like structures containing β-COP, ARF, and Rab5. Since HERC3 can itself be ubiquitinated and degraded by the proteasome, it likely has roles in both vesicular traffic and ubiquitin-dependent processes.[3][4][5]

HERC3
Identifiers
SymbolHERC3
Alt. namesHECT domain and RCC1-like domain-containing protein 3, HECT-type E3 ubiquitin transferase HERC3, KIAA0032
NCBI gene8916
HGNC4876
OMIM605200
PDBQ15034
RefSeqNM_001271602, NM_001318505 NM_014606, NM_001271602, NM_001318505
UniProtQ15034
Other data
EC number2.3.2.26
LocusChr. 4 q22.1:88,592,422-88,709,302
Search for
StructuresSwiss-model
DomainsInterPro

References

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  1. ^ Garcia-Gonzalo FR, Rosa JL (Aug 2005). "The HERC proteins: functional and evolutionary insights". Cell Mol Life Sci. 62 (16): 1826–1838. doi:10.1007/s00018-005-5119-y. PMC 11139159. PMID 15968461. S2CID 23391275.
  2. ^ Sánchez-Tena S, Cubillos-Rojas M, Schneider T, Rosa JL (May 2016). "Functional and pathological relevance of HERC family proteins: a decade later". Cell Mol Life Sci. 73 (10): 18955–1968. doi:10.1007/s00018-016-2139-8. PMC 11108380. PMID 26801221. S2CID 7457614.
  3. ^ Hochrainer K, Kroismayr R, Baranyi U, Binder BR, Lipp J (Jul 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell Mol Life Sci. 65 (13): 2105–2117. doi:10.1007/s00018-008-8148-5. PMC 11131906. PMID 18535780. S2CID 6897759.
  4. ^ Cruz C, Ventura F, Bartrons R, Rosa JL (Jan 2001). "HERC3 binding to and regulation by ubiquitin". FEBS Lett. 488 (1–2): 74–80. doi:10.1016/S0014-5793(00)02371-1. PMID 11163799. S2CID 20091003.
  5. ^ "Entrez Gene: HERC3".

Further reading

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