The HIF-1α internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of HIF-1α that allows cap-independent translation. The HIF-1α internal ribosome entry site (IRES) allows translation to be maintained under hypoxic cell conditions that inhibit cap-dependent translation [1]. The hypoxia-inducible factor-1α protein (HIF-1α) is a subunit of the HIF-1 transcription factor, which induces transcription of several genes involved in the cellular response to hypoxia.
| HIF-1 alpha IRES | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_HIF1 | |
| Identifiers | |
| Symbol | IRES_HIF1 |
| Rfam | RF00449 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
References
editFurther reading
edit- Lang KJ, Kappel A, Goodall GJ (May 2002). "Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia". Molecular Biology of the Cell. 13 (5): 1792–1801. doi:10.1091/mbc.02-02-0017. PMC 111144. PMID 12006670.
External links
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