Histone H2A type 1-H is a protein that in humans is encoded by the HIST1H2AH gene .[ 5] [ 6]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes . Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer , around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1 , interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.[ 6]
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