Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene .[ 5] [ 6] [ 7]
H2BC1 Identifiers Aliases H2BC1 , H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3, TH2B, histone cluster 1, H2ba, histone cluster 1 H2B family member a, hTSH2B, HIST1H2BA, H2B clustered histone 1External IDs OMIM : 609904 ; MGI : 2448375 ; HomoloGene : 69356 ; GeneCards : H2BC1 ; OMA :H2BC1 - orthologs Wikidata
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000146047 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050799 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics . 80 (5): 487–98. doi :10.1016/S0888-7543(02)96850-3 . PMID 12408966 .
^ Zalensky AO, Siino JS, Gineitis AA, Zalenskaya IA, Tomilin NV, Yau P, Bradbury EM (Nov 2002). "Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization" . J Biol Chem . 277 (45): 43474–80. doi :10.1074/jbc.M206065200 . PMID 12213818 .
^ a b "Entrez Gene: HIST1H2BA histone cluster 1, H2ba" .
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