Histone cluster 2 H3 family member a is a protein that in humans is encoded by the HIST2H3A gene. [5]

H3C15
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH3C15, H3/n, H3/o, histone cluster 2, H3a, histone cluster 2 H3 family member a, HIST2H3A, H3 clustered histone 15, H3C14, H3C13
External IDsMGI: 2448329; HomoloGene: 133885; GeneCards: H3C15; OMA:H3C15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005464

NM_013548

RefSeq (protein)

NP_066403
NP_001116847

Location (UCSC)Chr 1: 149.85 – 149.85 MbChr 13: 23.73 – 23.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on human chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000203852Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000100210Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Histone cluster 2 H3 family member a". Retrieved 2018-08-05.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.