HLA-B associated transcript 3

Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.

BAG6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WX9, 4DWF, 4EEW, 4WWR, 4X86, 2N9P
Identifiers
Aliases	BAG6, BAG-6, BAT3, D6S52E, G3, HLA-B associated transcript 3, BCL2 associated athanogene 6, BAG cochaperone 6
External IDs	OMIM: 142590; MGI: 1919439; HomoloGene: 3409; GeneCards: BAG6; OMA:BAG6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 31,639,028 bp End 31,652,705 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.59 cM Start 35,135,178 bp End 35,147,322 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis right lobe of thyroid gland right uterine tube apex of heart pituitary gland ganglionic eminence left lobe of thyroid gland anterior pituitary muscle of thigh Top expressed in seminiferous tubule spermatid spermatocyte neural layer of retina ventricular zone muscle of thigh superior frontal gyrus dentate gyrus of hippocampal formation granule cell yolk sac lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribosome binding misfolded protein binding Hsp70 protein binding polyubiquitin modification-dependent protein binding proteasome binding protein binding ubiquitin-specific protease binding ubiquitin protein ligase binding signaling receptor binding identical protein binding Cellular component cytoplasm cytosol membrane intracellular membrane-bounded organelle nucleoplasm BAT3 complex nucleus extracellular region extracellular exosome Biological process regulation of apoptotic process negative regulation of proteolysis intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator cell differentiation ubiquitin-dependent protein catabolic process kidney development embryo development lung development immune system process positive regulation of ERAD pathway protein stabilization negative regulation of apoptotic process internal peptidyl-lysine acetylation brain development intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of cell population proliferation synaptonemal complex assembly spermatogenesis negative regulation of proteasomal ubiquitin-dependent protein catabolic process protein localization to cytosolic proteasome complex involved in ERAD pathway maintenance of unfolded protein involved in ERAD pathway tail-anchored membrane protein insertion into ER membrane ER-associated misfolded protein catabolic process immune response-activating cell surface receptor signaling pathway apoptotic process natural killer cell activation proteasomal protein catabolic process ubiquitin-dependent ERAD pathway endoplasmic reticulum stress-induced pre-emptive quality control transport chromatin organization proteasome-mediated ubiquitin-dependent protein catabolic process regulation of embryonic development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7917 224727 Ensembl ENSG00000204463 ENSG00000228760 ENSG00000234651 ENSG00000229524 ENSG00000096155 ENSG00000227761 ENSG00000233348 ENSMUSG00000024392 UniProt P46379 Q9Z1R2 RefSeq (mRNA) NM_001098534 NM_001199697 NM_001199698 NM_004639 NM_080702 NM_080703 NM_001252468 NM_001252469 NM_057171 RefSeq (protein) NP_001092004 NP_001186626 NP_001186627 NP_542433 NP_542434 NP_001239397 NP_001239398 NP_476512 NP_001359189 NP_001359190 NP_001359191 NP_001359194 NP_001359195 NP_001359196 NP_001359197 NP_001359198 NP_001359199 NP_001359200 NP_001359201 NP_001359202 NP_001359203 NP_001359204 NP_001359205 NP_001359206 NP_001359207 NP_001359208 NP_001359209 NP_001359210 NP_001359211 NP_001359212 NP_001359213 NP_001359214 NP_001359215 NP_001359216 NP_001359217 NP_001359218 NP_001359219 NP_001359220 NP_001391257 NP_001391258 NP_001391259 NP_001391260 NP_001391256 Location (UCSC) Chr 6: 31.64 – 31.65 Mb Chr 17: 35.14 – 35.15 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is a nuclear protein. It has been implicated in the control of apoptosis and regulating heat shock protein. There are three alternatively spliced transcript variants described for this gene.

Further reading

• Takayama S, Reed JC (2001). "Molecular chaperone targeting and regulation by BAG family proteins". Nat. Cell Biol. 3 (10): E237–41. doi:10.1038/ncb1001-e237. PMID 11584289. S2CID 24466133.
• Cross SJ, Tonks S, Trowsdale J, Campbell RD (1992). "Novel detection of restriction fragment length polymorphisms in the human major histocompatibility complex". Immunogenetics. 34 (6): 376–84. doi:10.1007/BF01787488. PMID 1684176. S2CID 29262131.
• Spies T, Bresnahan M, Strominger JL (1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8955–8. Bibcode:1989PNAS...86.8955S. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.
• Spies T, Blanck G, Bresnahan M, et al. (1989). "A new cluster of genes within the human major histocompatibility complex". Science. 243 (4888): 214–7. Bibcode:1989Sci...243..214S. doi:10.1126/science.2911734. PMID 2911734.
• Ozaki T, Hanaoka E, Naka M, et al. (1999). "Cloning and characterization of rat BAT3 cDNA". DNA Cell Biol. 18 (6): 503–12. doi:10.1089/104454999315222. PMID 10390159.
• Thress K, Song J, Morimoto RI, Kornbluth S (2001). "Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper". EMBO J. 20 (5): 1033–41. doi:10.1093/emboj/20.5.1033. PMC 145500. PMID 11230127.
• Manchen ST, Hubberstey AV (2001). "Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis". Biochem. Biophys. Res. Commun. 287 (5): 1075–82. doi:10.1006/bbrc.2001.5701. PMID 11587531.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Wu YH, Shih SF, Lin JY (2004). "Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3". J. Biol. Chem. 279 (18): 19264–75. doi:10.1074/jbc.M307049200. PMID 14960581.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Kumar R, Lutz W, Frank E, Im HJ (2004). "Immediate early gene X-1 interacts with proteins that modulate apoptosis". Biochem. Biophys. Res. Commun. 323 (4): 1293–8. doi:10.1016/j.bbrc.2004.09.006. PMC 2895269. PMID 15451437.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.