HLA-DR10


major histocompatibility complex, class II, DR10
Haplotypes groups	DQA01:DRB11001
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA^{[permanent dead link]}
EBI-HLA	DRA*0101
Identifiers	beta 1 *1001
Symbol(s)	HLA-DRB1^{[permanent dead link]}
EBI-HLA	DRB1*1001
Shared data
Locus	chr.6 6p21.31

HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.

Serology

DR10 serotype recognition of the DRB1*1001 allele gene product^[1]
DRB1*	DR10	DR1		Sample
allele	%	%	%	size (N)
1001	90	4		894

The serological reaction of DR10 is relatively good.

Disease associations

By serotype

DR10 serotype or cognate alleles are associated with: Lichen planus^[2]

By allele

DRB1*1001 is associated with ovarian cancer^[3] and invasive squamous cell cervical cancer (SCC)^[4]

Extended linkage

DRB1*1001:DQA1*01:DQB1*05 haplotype: Rheumatoid arthritis^[5] The primary involvement appears to be DR10.

Genetic Linkage

DR10 Haplotypes
	DRA	DRB1
Haplotypes	*0101	*1001
	DQA1	DQB1	DRB1
Haplotypes	*0101	*0501	*1001
	HLA-A	HLA-B	DRB1
Haplotypes	*0000	*0000	*1001

HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5.

References

^ derived from IMGT/HLA
^ White A, Rostom A (1994). "HLA antigens in Arabs with lichen planus". Clinical and Experimental Dermatology. 19 (3): 236–7. doi:10.1111/j.1365-2230.1994.tb01174.x. PMID 8033385. S2CID 27001518.
^ Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K (2006). "HLA-class II haplotype associations with ovarian cancer". Int J Cancer. 119 (12): 2980–5. doi:10.1002/ijc.22266. PMID 17016821.
^ Madeleine M, Brumback B, Cushing-Haugen K, Schwartz S, Daling J, Smith A, Nelson J, Porter P, Shera K, McDougall J, Galloway D (2002). "Human leukocyte antigen class II and cervical cancer risk: a population-based study". J Infect Dis. 186 (11): 1565–74. doi:10.1086/345285. PMID 12447731.
^ Pascual M, Nieto A, López-Nevot M, Ramal L, Matarán L, Caballero A, Alonso A, Martín J, Zanelli E (2001). "Rheumatoid arthritis in southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition". Arthritis Rheum. 44 (2): 307–14. doi:10.1002/1529-0131(200102)44:2<307::AID-ANR47>3.0.CO;2-K. PMID 11229460.

[1] rived from IMGT/HLA

[2] White A, Rostom A (1994). "HLA antigens in Arabs with lichen planus". Clinical and Experimental Dermatology. 19 (3): 236–7. doi:10.1111/j.1365-2230.1994.tb01174.x. PMID 8033385. S2CID 27001518.

[3] Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K (2006). "HLA-class II haplotype associations with ovarian cancer". Int J Cancer. 119 (12): 2980–5. doi:10.1002/ijc.22266. PMID 17016821.

[4] Madeleine M, Brumback B, Cushing-Haugen K, Schwartz S, Daling J, Smith A, Nelson J, Porter P, Shera K, McDougall J, Galloway D (2002). "Human leukocyte antigen class II and cervical cancer risk: a population-based study". J Infect Dis. 186 (11): 1565–74. doi:10.1086/345285. PMID 12447731.

[5] Pascual M, Nieto A, López-Nevot M, Ramal L, Matarán L, Caballero A, Alonso A, Martín J, Zanelli E (2001). "Rheumatoid arthritis in southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition". Arthritis Rheum. 44 (2): 307–14. doi:10.1002/1529-0131(200102)44:2<307::AID-ANR47>3.0.CO;2-K. PMID 11229460.

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