HLA-DR51


major histocompatibility complex, class II, DR51
Haplotypes groups	DRA01:DRB501 DRA01:DRB502
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA^{[permanent dead link]}
EBI-HLA	DRA*0101
Identifiers	beta 5 01 02
Symbol(s)	HLA-DRB5^{[permanent dead link]}
EBI-HLA	DRB5*01
EBI-HLA	DRB5*02 Archived 2011-05-15 at the Wayback Machine
Shared data
Locus	chr.6 6p21.31

HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.

DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution,^[1] having diverged from DRB1 approximately 4 million years ago.^[2]

DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB5.

Alleles

DR52 recognition of some DRB3* alleles^[3]
DRB5*	DR51	?	Sample
allele	%	%	size (N)
0101	>71		28
0102	>86		8
0202	>86		13

DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.

DRB5*01 allele group

14 Alleles: 11 proteins, 2 Nulls
DR51 Serotype: *0101, *0102
Serotype unknown: *0103 to *0107, *0109, *0110 to *0113
Nulls: *0108N, *0110N

DRB5*02 allele group

4 Alleles: 4 proteins
DR51 Serotype: *0202,
Serotype unknown: *0203 to *0205

Associated diseases

DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:

DRB5*0101:DRB1*1501 Multiple sclerosis,^[4] leprosy^[5]

DRB1 linkage

HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups.

HLA-DR2

HLA-DR15 - DRB1*15
HLA-DR16 - DRB1*16

References

^ Gorski J, Rollini P, Mach B (1987). "Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic". Immunogenetics. 25 (6): 397–402. doi:10.1007/BF00396106. PMID 3596674. S2CID 25853147.
^ Gongora R, Figueroa F, Klein J (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol. 51 (1): 23–31. doi:10.1016/S0198-8859(96)00189-9. PMID 8911994.
^ derived from IMGT/HLA
^ Sospedra M, Muraro P, Stefanová I, Zhao Y, Chung K, Li Y, Giulianotti M, Simon R, Mariuzza R, Pinilla C, Martin R (2006). "Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype". J Immunol. 176 (3): 1951–61. doi:10.4049/jimmunol.176.3.1951. PMC 2746197. PMID 16424227.
^ Joko S, Numaga J, Kawashima H, Namisato M, Maeda H (2000). "Human leukocyte antigens in forms of leprosy among Japanese patients". Int J Lepr Other Mycobact Dis. 68 (1): 49–56. PMID 10834069.

[pmid3596674-1] Gorski J, Rollini P, Mach B (1987). "Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic". Immunogenetics. 25 (6): 397–402. doi:10.1007/BF00396106. PMID 3596674. S2CID 25853147.

[pmid8911994-2] Gongora R, Figueroa F, Klein J (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol. 51 (1): 23–31. doi:10.1016/S0198-8859(96)00189-9. PMID 8911994.

[3] rived from IMGT/HLA

[4] Sospedra M, Muraro P, Stefanová I, Zhao Y, Chung K, Li Y, Giulianotti M, Simon R, Mariuzza R, Pinilla C, Martin R (2006). "Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype". J Immunol. 176 (3): 1951–61. doi:10.4049/jimmunol.176.3.1951. PMC 2746197. PMID 16424227.

[5] Joko S, Numaga J, Kawashima H, Namisato M, Maeda H (2000). "Human leukocyte antigens in forms of leprosy among Japanese patients". Int J Lepr Other Mycobact Dis. 68 (1): 49–56. PMID 10834069.

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