| |
human major histocompatibility complex, class II, DR8
| |
| Haplotypes groups | DQA*01:DRB1*0801 to
DQA*01:DRB1*0806 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
|
| Symbol(s) | HLA-DRA[permanent dead link] |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *0801 to *0806
|
| Symbol(s) | HLA-DRB1[permanent dead link] |
| EBI-HLA | DRB1*0801 |
| EBI-HLA | DRB1*0802 |
| EBI-HLA | DRB1*0803 |
| EBI-HLA | DRB1*0804 |
| EBI-HLA | DRB1*0805 |
| EBI-HLA | DRB1*0806 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.
Serology
edit| DRB1* | DR8 | Sample |
| allele | % | size (N) |
| 0801 | 95 | 1076 |
| 0802 | 96 | 265 |
| 0803 | 88 | 230[2] |
| 0804 | 93 | 186 |
| 0805 | >60 | 5 |
| 0806 | >75 | 13 |
The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.
Disease associations
editDR8 is linked to papillary thyroid carcinomas,[3] early onset pauciarticular juvenile chronic arthritis,[4][5] primary biliary cirrhosis[6]
by allele
editHLA-DRB1*0801 is linked to primary biliary cirrhosis[7] In Mexicans DR8 is found more often in type-2 juvenile diabetes.[8]
HLA-DRB1*0803 is also linked to primary biliary cirrhosis[7]
Genetic Linkage
editDR8 Haplotypes
| |||
| DRA | DRB1 | ||
|---|---|---|---|
| Haplotypes | *0101 | *0801 | *0101 |
| DQA1 | DQB1 | DRB1 | |
| Haplotypes | *0401 | *0402 | *0801 |
| HLA-A | HLA-B | DRB1 | |
| Haplotypes | *0000 | *0000 | *0801 |
HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.
References
edit- ^ derived from IMGT/HLA
- ^ DR12 - 3%
- ^ Porto T, Coelho I, Boavida J, Pereira C, Nunes J, Mendonça D, Martins B, Sobrinho L, Leite V (2006). "Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas". Clin Endocrinol. 64 (2): 179–83. doi:10.1111/j.1365-2265.2006.02445.x. PMID 16430717. S2CID 22695710.
- ^ Haas J, Truckenbrodt H, Paul C, Hoza J, Scholz S, Albert E (1994). "Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis". Clin Exp Rheumatol. 12 (Suppl 10): S7–14. PMID 7955632.
- ^ Säilä H, Pitkäniemi J, Tuomilehto J, Savolainen A, Alakulppi N, Tuomilehto-Wolf E, Leirisalo-Repo M, Aho K (2004). "HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population". J Rheumatol. 31 (11): 2281–5. PMID 15517645.
- ^ Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R (1992). "Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype". Hepatology. 16 (6): 1404–8. doi:10.1002/hep.1840160616. PMID 1359995. S2CID 7200339.
- ^ a b Charatcharoenwitthaya P, Lindor K (2005). "Current concepts in the pathogenesis of primary biliary cirrhosis". Ann Hepatol. 4 (3): 161–75. doi:10.1016/S1665-2681(19)32061-7. PMID 16177655.
- ^ Rodríguez-Ventura AL, Yamamoto-Furusho JK, Coyote N, et al. (2007). "HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children". Pediatric Diabetes. 8 (1): 5–10. doi:10.1111/j.1399-5448.2006.00221.x. PMID 17341285. S2CID 35352151.