HNRNPA0

Heterogeneous nuclear ribonucleoprotein A0 is a protein that in humans is encoded by the HNRNPA0 gene.

HNRNPA0
Identifiers
Aliases	HNRNPA0, HNRPA0, heterogeneous nuclear ribonucleoprotein A0
External IDs	OMIM: 609409; MGI: 1924384; HomoloGene: 136809; GeneCards: HNRNPA0; OMA:HNRNPA0 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.2 Start 137,745,651 bp End 137,754,363 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 B1 Start 58,273,693 bp End 58,276,370 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium endothelial cell middle temporal gyrus embryo tail of epididymis retinal pigment epithelium lactiferous duct cartilage tissue pons caput epididymis Top expressed in hand otolith organ utricle ganglionic eminence abdominal wall primitive streak medial ganglionic eminence ventricular zone hair follicle vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase binding nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR AU-rich region binding Cellular component nucleoplasm nucleus ribonucleoprotein complex Biological process mRNA splicing, via spliceosome mRNA processing 3'-UTR-mediated mRNA stabilization inflammatory response response to lipopolysaccharide RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10949 77134 Ensembl ENSG00000177733 ENSMUSG00000007836 UniProt Q13151 Q9CX86 RefSeq (mRNA) NM_006805 NM_029872 RefSeq (protein) NP_006796 NP_084148 Location (UCSC) Chr 5: 137.75 – 137.75 Mb Chr 13: 58.27 – 58.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.
• Li SH, McInnis MG, Margolis RL, et al. (1993). "Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms". Genomics. 16 (3): 572–9. doi:10.1006/geno.1993.1232. PMID 8325628.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Lai F, Godley LA, Joslin J, et al. (2001). "Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)". Genomics. 71 (2): 235–45. doi:10.1006/geno.2000.6414. PMID 11161817.
• Rousseau S, Morrice N, Peggie M, et al. (2003). "Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs". EMBO J. 21 (23): 6505–14. doi:10.1093/emboj/cdf639. PMC 136943. PMID 12456657.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nat. Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174. S2CID 6654604.