HOXB3

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.

HOXB3
Identifiers
Aliases	HOXB3, HOX2, HOX2G, Hox-2.7, homeobox B3
External IDs	OMIM: 142966; MGI: 96184; HomoloGene: 1617; GeneCards: HOXB3; OMA:HOXB3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.32 Start 48,548,870 bp End 48,604,912 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 59.84 cM Start 96,214,152 bp End 96,238,756 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube corpus epididymis caput epididymis seminal vesicula gastric mucosa muscle layer of sigmoid colon tail of epididymis transverse colon beta cell endometrium Top expressed in efferent ductule migratory enteric neural crest cell tail of embryo vas deferens medullary collecting duct inferior ganglion of vagus nerve hair follicle abdominal wall Paneth cell thoracic vertebral column More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process embryonic skeletal system morphogenesis multicellular organism development glossopharyngeal nerve morphogenesis definitive hemopoiesis thyroid gland development cartilage development face development regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of neurogenesis rhombomere development angiogenesis hematopoietic progenitor cell differentiation transcription, DNA-templated anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3213 15410 Ensembl ENSG00000120093 ENSMUSG00000048763 UniProt P14651 P09026 RefSeq (mRNA) NM_002146 NM_001330322 NM_001330323 NM_001384747 NM_001384749 NM_001384750 NM_001079869 NM_010458 RefSeq (protein) NP_001317251 NP_001317252 NP_002137 NP_001073338 NP_034588 Location (UCSC) Chr 17: 48.55 – 48.6 Mb Chr 11: 96.21 – 96.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).

See also

• Homeobox

Further reading

• Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
• Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
• Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339–47. doi:10.1002/j.1460-2075.1994.tb06636.x. PMC 395231. PMID 7913891.
• Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Bingle CD, Gowan S (1996). "Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter". Biochem. J. 319 ( Pt 3) (Pt 3): 669–74. doi:10.1042/bj3190669. PMC 1217841. PMID 8920965.
• Sauvageau G, Thorsteinsdottir U, Hough MR, et al. (1997). "Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation". Immunity. 6 (1): 13–22. doi:10.1016/S1074-7613(00)80238-1. PMID 9052833.
• Guazzi S, Pintonello ML, Viganò A, Boncinelli E (1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". J. Biol. Chem. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.
• Viganò MA, Di Rocco G, Zappavigna V, Mavilio F (1998). "Definition of the Transcriptional Activation Domains of Three Human HOX Proteins Depends on the DNA-Binding Context". Mol. Cell. Biol. 18 (11): 6201–12. doi:10.1128/MCB.18.11.6201. PMC 109207. PMID 9774637.
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Nakamura N, Yoshimi T, Miura T (2002). "Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3". Cell Growth Differ. 13 (4): 195–203. PMID 11971819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Pineault N, Abramovich C, Ohta H, Humphries RK (2004). "Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1". Mol. Cell. Biol. 24 (5): 1907–17. doi:10.1128/MCB.24.5.1907-1917.2004. PMC 350554. PMID 14966272.
• Roche J, Zeng C, Barón A, et al. (2004). "Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics". Leukemia. 18 (6): 1059–63. doi:10.1038/sj.leu.2403366. PMID 15085154. S2CID 9417756.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Speleman F, Cauwelier B, Dastugue N, et al. (2005). "A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias". Leukemia. 19 (3): 358–66. doi:10.1038/sj.leu.2403657. hdl:1854/LU-349753. PMID 15674412.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• HOXB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.