HOXC4

Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

HOXC4
Identifiers
Aliases	HOXC4, HOX3, HOX3E, cp19, homeobox C4
External IDs	OMIM: 142974; MGI: 96195; HomoloGene: 8408; GeneCards: HOXC4; OMA:HOXC4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.13 Start 54,016,931 bp End 54,056,030 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 F3|15 58.08 cM Start 102,927,366 bp End 102,945,278 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube vena cava renal medulla saphenous vein pons left uterine tube tibial arteries caput epididymis testicle spinal ganglia Top expressed in superior cervical ganglion tail of embryo efferent ductule dermis abdominal wall somite esophagus epididymis cumulus cell migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding HMG box domain binding DNA binding protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus Biological process multicellular organism development skeletal system development cartilage development regulation of transcription, DNA-templated embryonic organ morphogenesis transcription, DNA-templated anterior/posterior pattern specification transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II embryonic skeletal system morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3221 15423 Ensembl ENSG00000198353 ENSMUSG00000075394 UniProt P09017 Q86TF7 Q08624 RefSeq (mRNA) NM_153633 NM_014620 NM_013553 RefSeq (protein) NP_055435 NP_705897 NP_055435.2 NP_705897.1 NP_038581 Location (UCSC) Chr 12: 54.02 – 54.06 Mb Chr 15: 102.93 – 102.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.

See also

• Homeobox

Interactions

HOXC4 has been shown to interact with Ku70.

Further reading

• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (1989). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1989). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. Bibcode:1986PNAS...83.9104R. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432.
• Simeone A, Pannese M, Acampora D, D'Esposito M, Boncinelli E (1988). "At least three human homeoboxes on chromosome 12 belong to the same transcription unit". Nucleic Acids Res. 16 (12): 5379–90. doi:10.1093/nar/16.12.5379. PMC 336773. PMID 2898768.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Meazza R, Faiella A, Corsetti MT, Airoldi I, Ferrini S, Boncinelli E, Corte G (1995). "Expression of HOXC4 homeoprotein in the nucleus of activated human lymphocytes". Blood. 85 (8): 2084–90. doi:10.1182/blood.V85.8.2084.bloodjournal8582084. PMID 7718879.
• Rieger E, Bijl JJ, van Oostveen JW, Soyer HP, Oudejans CB, Jiwa NM, Walboomers JM, Meijer CJ (1994). "Expression of the homeobox gene HOXC4 in keratinocytes of normal skin and epithelial skin tumors is correlated with differentiation". J. Invest. Dermatol. 103 (3): 341–6. doi:10.1111/1523-1747.ep12394888. PMID 7915745.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Bijl JJ, Rieger E, van Oostveen JW, Walboomers JM, Kreike M, Willemze R, Meijer CJ (1997). "HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas". Am. J. Pathol. 151 (4): 1067–74. PMC 1858029. PMID 9327740.
• Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ (2001). "The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase". J. Biol. Chem. 276 (20): 16848–56. doi:10.1074/jbc.M100768200. PMID 11279128.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Schaffer A, Kim EC, Wu X, Zan H, Testoni L, Salamon S, Cerutti A, Casali P (2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements". J. Biol. Chem. 278 (25): 23141–50. doi:10.1074/jbc.M212952200. PMID 12672812.
• Kim EC, Edmonston CR, Wu X, Schaffer A, Casali P (2004). "The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination". J. Biol. Chem. 279 (40): 42258–69. doi:10.1074/jbc.M407496200. PMC 4631311. PMID 15252056.
• Speleman F, Cauwelier B, Dastugue N, Cools J, Verhasselt B, Poppe B, Van Roy N, Vandesompele J, Graux C, Uyttebroeck A, Boogaerts M, De Moerloose B, Benoit Y, Selleslag D, Billiet J, Robert A, Huguet F, Vandenberghe P, De Paepe A, Marynen P, Hagemeijer A (2005). "A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias". Leukemia. 19 (3): 358–66. doi:10.1038/sj.leu.2403657. hdl:1854/LU-349753. PMID 15674412.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.

External links

• HOXC4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.