Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.[5][6][7]

HOXD4
Identifiers
AliasesHOXD4, HHO.C13, HOX-5.1, HOX4, HOX4B, Hox-4.2, homeobox D4
External IDsOMIM: 142981; MGI: 96208; HomoloGene: 7773; GeneCards: HOXD4; OMA:HOXD4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014621

NM_010469

RefSeq (protein)

NP_055436

NP_034599

Location (UCSC)Chr 2: 176.15 – 176.15 MbChr 2: 74.54 – 74.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined.[7]

See also

edit

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170166Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000101174Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. ^ a b "Entrez Gene: HOXD4 homeobox D4".

Further reading

edit
edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.