Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene .[ 5] [ 6]
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system.[ 6]
Role in breast cancer
The HS3ST2 promoter is hypermethylated in breast cancer tissue compared to normal breast ducts, suggesting a potential involvement in the pathogenesis of the disease.[ 7] breast cancer cells resulted in altered invasiveness, which was due to changes in Mitogen-activated protein kinase signaling and matrix metalloproteinase expression.[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000122254 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046321 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (Mar 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci" . J Biol Chem . 274 (8): 5170–84. doi :10.1074/jbc.274.8.5170 PMID 9988767 . ^ a b "Entrez Gene: HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2" .^ Dietrich D (2009). "Analysis of DNA Methylation of Multiple Genes in Microdissected Cells From Formalin-fixed and Paraffin-embedded Tissues" . Journal of Histochemistry and Cytochemistry . 57 (5): 477–489. doi :10.1369/jhc.2009.953026 . PMC 2674771 PMID 19153192 . ^ Vijaya Kumar A (2014). "HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression" . International Journal of Cancer . 135 (11): 2579–92. doi :10.1002/ijc.28921 PMID 24752740 . S2CID 205950148 .
Lawrence R, Yabe T, Hajmohammadi S, et al. (2007). "The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues" . Matrix Biol . 26 (6): 442–55. doi :10.1016/j.matbio.2007.03.002 . PMC 1993827 PMID 17482450 . O'Donnell CD, Tiwari V, Oh MJ, Shukla D (2006). "A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread" . Virology . 346 (2): 452–9. doi :10.1016/j.virol.2005.11.003 PMID 16336986 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Miyamoto K, Asada K, Fukutomi T, et al. (2003). "Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers" . Oncogene . 22 (2): 274–80. doi :10.1038/sj.onc.1206146 PMID 12527896 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Liu J, Shworak NW, Sinaÿ P, et al. (1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities" . J. Biol. Chem . 274 (8): 5185–92. doi :10.1074/jbc.274.8.5185 PMID 9988768 . Razi N, Lindahl U (1995). "Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides" . J. Biol. Chem . 270 (19): 11267–75. doi :10.1074/jbc.270.19.11267 PMID 7744762 .
