Wikipedia

Halocidin

Halocidin is an antimicrobial peptide isolated from the Halocynthia aurantium species of tunicate.[1][2] In mouse models, derivative peptides have shown efficacy in the treatment of fungicidal resistant Candida Albacans when used as a mouthwash additive.[3]

Halocidin
Identifiers
3D model (JSmol)
ChEMBL
  • InChI=1S/C155H251N47O38S2/c1-73(2)41-100(181-121(206)63-170-134(217)109(51-91-59-163-69-172-91)190-146(229)111(53-93-61-165-71-174-93)192-144(227)107(48-80(15)16)188-141(224)104(45-77(9)10)185-127(210)84(23)158)139(222)195-114(56-119(161)204)148(231)199-116(150(233)177-85(24)128(211)183-98(37-31-33-39-156)132(215)168-65-123(208)201-125(82(19)20)152(235)197-102(43-75(5)6)136(219)179-88(27)154(237)238)67-241-242-68-117(151(234)178-86(25)129(212)184-99(38-32-34-40-157)133(216)169-66-124(209)202-126(83(21)22)153(236)198-103(44-76(7)8)137(220)180-89(28)155(239)240)200-149(232)115(57-120(162)205)196-140(223)101(42-74(3)4)182-122(207)64-171-135(218)110(52-92-60-164-70-173-92)191-147(230)112(54-94-62-166-72-175-94)193-145(228)108(49-81(17)18)189-142(225)105(46-78(11)12)186-130(213)87(26)176-138(221)113(55-118(160)203)194-143(226)106(47-79(13)14)187-131(214)96(159)50-90-58-167-97-36-30-29-35-95(90)97/h29-30,35-36,58-62,69-89,96,98-117,125-126,167H,31-34,37-57,63-68,156-159H2,1-28H3,(H2,160,203)(H2,161,204)(H2,162,205)(H,163,172)(H,164,173)(H,165,174)(H,166,175)(H,168,215)(H,169,216)(H,170,217)(H,171,218)(H,176,221)(H,177,233)(H,178,234)(H,179,219)(H,180,220)(H,181,206)(H,182,207)(H,183,211)(H,184,212)(H,185,210)(H,186,213)(H,187,214)(H,188,224)(H,189,225)(H,190,229)(H,191,230)(H,192,227)(H,193,228)(H,194,226)(H,195,222)(H,196,223)(H,197,235)(H,198,236)(H,199,231)(H,200,232)(H,201,208)(H,202,209)(H,237,238)(H,239,240)
    Key: VOWRCIUWDITXFQ-UHFFFAOYSA-N
  • CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CSSCC(C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC3=CNC4=CC=CC=C43)N)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)NC(=O)CNC(=O)C(CC5=CN=CN5)NC(=O)C(CC6=CN=CN6)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C)N
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

References

edit
  1. ^ Jang WS, Kim KN, Lee YS, Nam MH, Lee IH (June 2002). "Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium". FEBS Letters. 521 (1–3): 81–6. Bibcode:2002FEBSL.521...81J. doi:10.1016/s0014-5793(02)02827-2. PMID 12067731. S2CID 45780988.
  2. ^ Jang WS, Lee SC, Lee YS, Shin YP, Shin KH, Sung BH, et al. (November 2007). "Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection". Antimicrobial Agents and Chemotherapy. 51 (11): 4148–4156. doi:10.1128/AAC.00635-07. PMC 2151467. PMID 17846130.
  3. ^ Shin SH, Lee YS, Shin YP, Kim B, Kim MH, Chang HR, et al. (May 2013). "Therapeutic efficacy of halocidin-derived peptide HG1 in a mouse model of Candida albicans oral infection". The Journal of Antimicrobial Chemotherapy. 68 (5): 1152–1160. doi:10.1093/jac/dks513. PMID 23302580.
 

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