Haloxazolam

Haloxazolam
Clinical data
Trade names	Somelin (JP)
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Anlage III (Special prescription form required); US: Schedule IV;
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
	IUPAC name 10-bromo-11b-(2-fluorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one;
CAS Number	59128-97-1 ;
PubChem CID	3563;
DrugBank	DB01476 ;
ChemSpider	3442 ;
UNII	M448L2V8XP;
KEGG	D01758 ;
ChEMBL	ChEMBL2104461 ;
CompTox Dashboard (EPA)	DTXSID60866740 ;
Chemical and physical data
Formula	C17H14BrFN2O2
Molar mass	377.213 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc1ccccc1C42OCCN2CC(=O)Nc3c4cc(Br)cc3;
	InChI InChI=1S/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22) ; Key:XDKCGKQHVBOOHC-UHFFFAOYSA-N ;
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Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.^[2]^[3]^[4] It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment of insomnia.^[5] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons.^[6]

References

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Tanaka E, Terada M, Misawa S, Wakasugi C (June 1996). "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of Chromatography B: Biomedical Sciences and Applications. 682 (1): 173–8. doi:10.1016/0378-4347(96)00121-1. PMID 8832439.
^ "Benzodiazepine Names". non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2009-04-05.
^ Guan F, Seno H, Ishii A, Watanabe K, Kumazawa T, Hattori H, Suzuki O (1999). "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of Analytical Toxicology. 23 (1): 54–61. doi:10.1093/jat/23.1.54. PMID 10022210.
^ Tan X, Uchida S, Matsuura M, Nishihara K, Kojima T (February 2003). "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra". Psychiatry and Clinical Neurosciences. 57 (1): 97–104. doi:10.1046/j.1440-1819.2003.01085.x. PMID 12519461. S2CID 20863635.
^ Sakai Y (October 1983). "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems". Japanese Journal of Pharmacology. 33 (5): 1017–25. doi:10.1254/jjp.33.1017. PMID 6139494.

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[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] Tanaka E, Terada M, Misawa S, Wakasugi C (June 1996). "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of Chromatography B: Biomedical Sciences and Applications. 682 (1): 173–8. doi:10.1016/0378-4347(96)00121-1. PMID 8832439.

[3] "Benzodiazepine Names". non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2009-04-05.

[4] Guan F, Seno H, Ishii A, Watanabe K, Kumazawa T, Hattori H, Suzuki O (1999). "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of Analytical Toxicology. 23 (1): 54–61. doi:10.1093/jat/23.1.54. PMID 10022210.

[5] Tan X, Uchida S, Matsuura M, Nishihara K, Kojima T (February 2003). "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra". Psychiatry and Clinical Neurosciences. 57 (1): 97–104. doi:10.1046/j.1440-1819.2003.01085.x. PMID 12519461. S2CID 20863635.

[6] Sakai Y (October 1983). "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems". Japanese Journal of Pharmacology. 33 (5): 1017–25. doi:10.1254/jjp.33.1017. PMID 6139494.

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[1]

Haloxazolam

See also

References