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Haplogroup JT

Haplogroup JT is a human mitochondrial DNA (mtDNA) haplogroup.

Haplogroup JT
Possible time of origin50,300 YBP
Possible place of originSouthwest Asia
AncestorR2'JT
DescendantsJ, T
Defining mutations11251, 15452A, 16126[1]

Origin

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Haplogroup JT is descended from the macro-haplogroup R. It is the ancestral clade to the mitochondrial haplogroups J and T.

Distribution

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JT (predominantly J) was found among the ancient Etruscans.[2] The root level haplogroup JT* has been assigned to an ancient person found at the Colfiorito necropolis in Umbria in central Italy.[3]

The haplogroup has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Taforalt prehistoric site.[4] One ancient individual carried a haplotype, which correlates with either the JT clade or the haplogroup H subclade H14b1 (1/9; 11%).[5]

Subclades

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Tree

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This phylogenetic tree of haplogroup JT subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[1] and subsequent published research.

  • R2'JT

Health

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Maternally inherited ancient mtDNA variants have clear impact on the presentation of disease in a modern society. Superhaplogroup JT is an example of reduced risk of Parkinson's disease[6] And mitochondrial and mtDNa alterations continue to be promising disease biomarkers.[7][8]

See also

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Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6  
L1 L2   L3     L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T

References

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  1. ^ a b van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457.
  2. ^ "We Are Not Our Ancestors". Archived from the original on 2009-04-08. Retrieved 2012-02-10.
  3. ^ GenBank Accession number: MN687309.1
  4. ^ Bernard Secher; Rosa Fregel; José M Larruga; Vicente M Cabrera; Phillip Endicott; José J Pestano; Ana M González (2014). "The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents". BMC Evolutionary Biology. 14 (1): 109. Bibcode:2014BMCEE..14..109S. doi:10.1186/1471-2148-14-109. PMC 4062890. PMID 24885141.
  5. ^ Kefi, Rym; et al. (2016). "On the origin of Iberomaurusians: new data based on ancient mitochondrial DNA and phylogenetic analysis of Afalou and Taforalt populations". Mitochondrial DNA Part A. 29 (1): 147–157. doi:10.1080/24701394.2016.1258406. PMID 28034339. S2CID 4490910.
  6. ^ Marom S, Friger M, Mishmar D (February 2017). "MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association". Sci Rep. 7: 43449. doi:10.1038/srep43449. PMC 5322532. PMID 28230165.
  7. ^ Martín-Jiménez R, Lurette O, Hebert-Chatelain E (August 2020). "Damage in Mitochondrial DNA Associated with Parkinson's Disease". DNA Cell Biol. 39 (8): 1421–1430. doi:10.1089/dna.2020.5398. PMID 32397749.
  8. ^ Lowes H, Pyle A, Duddy M, Hudson G (May 2019). "Cell-free mitochondrial DNA in progressive multiple sclerosis". Mitochondrion. 46: 307–312. doi:10.1016/j.mito.2018.07.008. PMC 6509276. PMID 30098422.
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