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Heat Biologics Inc. is a U.S. biotechnology company focused on the field of immunotherapy. Heat Biologics was founded by Jeff Wolf and Eckhard Podack, in conjunction with the University of Miami and Seed-One Ventures.[3] The company is based in Morrisville, North Carolina.[2]
| Company type | Public |
|---|---|
| Nasdaq: HTBX[1] | |
| Industry | Biotechnology |
| Founded | 2008 |
| Headquarters | Morrisville, North Carolina, U.S.[2] |
Area served | Morrisville, North Carolina,[2] New Brunswick, New Jersey,[2] and San Antonio, Texas, U.S.[2] |
Key people | Jeffrey Wolf (Founder and CEO) |
| Products | HS-110, HS-130, PTX-35 and COVID-19 program |
| Website | heatbio |
History
editIn 2008, Heat Biologics was founded by Jeff Wolf and Eckhard Podack, in conjunction with the University of Miami and Seed-One Ventures.[3] The company relocated to North Carolina in 2011.[2] NCBiotech provided $225,000 of initial funding the same year.[2]
On July 24, 2013, Heat Biologics stock went public on NASDAQ under ticker symbol HTBX.[1]
In 2017, Heat Biologics acquired an 80% controlling interest in Pelican Therapeutics.[4]
Morrisville, North Carolina became the company's headquarters in 2019.[2]
In 2020, the Miller School of Medicine at the University of Miami collaborated with Heat Biologics to develop a COVID-19 vaccine using gp-96 to express antigens associated with COVID-19.[5]
In 2021, Heat Biologics began Phase 2 clinical trials for a new non-small cell lung cancer treatment (HS-110). It also initiated a Phase 1 trial for HS-130, its off-the-shelf cell line engineered to stimulate T-cells to assist in immune response to disease.[2]
Pipeline products
editHS-110
editHS-110, also called viagenpumatucel-L, is in Phase II in NSCLC, in combination with cyclophosphamide. Another Phase I study is combining HS 110 with nivolumab and other checkpoint inhibitors.[6]
HS-130
editHS-130 is in Phase I clinical trial for patients with solid tumors. HS-130 is an allogeneic (“off-the-shelf”) cell line engineered to express OX40 ligand fusion protein (OX40L-Fc). OX40 ligand is a key co-stimulator of T cells that augments antigen-specific CD8+ T cell responses.[7]
COVID-19 Vaccine
editThe company initiated a COVID-19 vaccine collaboration with the University of Miami in March 2020 using their gp96 platform which activates the human immune system to combat infectious diseases with the potential of generating long-term immune responses.[8]
PTX-35
editPTX-35 is in Phase I clinical trial for patients with solid tumors. PTX-35 is a potential first-in-class T cell co-stimulator targeting TNFRSF25 (Death Receptor 3). Favorable safety profile was demonstrated in mice and non-human primates. PTX-35's development plan focuses on cancer immunotherapy.[9]
References
edit- ^ a b "Heat Biologics, Inc. Announces Closing of Initial Public Offering of 2,500,000 Shares of Common Stock". Heatbio.com. July 29, 2013. Archived from the original on 2016-03-04. Retrieved 1 January 2016.
- ^ a b c d e f g h i Bryant Haskins (June 24, 2021). "Heat Biologics To Double Size of Morrisville R&D Center". North Carolina Biotechnology Center.
- ^ a b Howard Cohen (October 15, 2015). "Dr. Eckhard Podack, University of Miami cancer researcher, dies at 72". Miami Herald.
- ^ Allan Maurer (November 3, 2020). "'Synergy' Behind Heat Biologics/Pelican deal is Key to Immunology". North Carolina Biotechnology Center.
- ^ Richard Westlund (March 18, 2020). "Immunology researchers at the University of Miami Miller School of Medicine are collaborating with North Carolina-based Heat Biologics, Inc. to develop a vaccine for the novel coronavirus COVID-19". Miller School of Medicine.
- ^ Heat Biologics (2020-01-24). "A Phase 2, Multicenter, Randomized Study to Evaluate the Safety and Efficacy of Viagenpumatucel-L (HS-110) in Combination With Low Dose (Metronomic) Cyclophosphamide Versus Chemotherapy Alone in Patients With Non-Small Cell Lung Adenocarcinoma After Failure of Two or Three Previous Treatment Regimens for Advanced Disease".
{{cite journal}}: Cite journal requires|journal=(help) - ^ Heat Biologics (2020-09-14). "A Phase I, First-in-human, Dose-escalation Study to Evaluate the Safety and Immunologic Response After Administration of HS-130 in Combination With HS-110 (Viagenpumatucel-L) in Patients With Solid Tumors Refractory to Standard Care".
{{cite journal}}: Cite journal requires|journal=(help) - ^ "Heat Biologics and University of Miami - gp96-Ig-S". GEN - Genetic Engineering and Biotechnology News. 2020-05-18. Retrieved 2021-01-12.
- ^ "Heat Biologics Announces First Patient Treated in First-in-Human Clinical Trial of PTX-35". BioSpace. Retrieved 2021-01-12.