The heat shock protein 70 (Hsp70) internal ribosome entry site (IRES) is an RNA element that allows cap independent translation during conditions such as heat shock and stress. It has been shown that the 216 nucleotide long 5' UTR contains internal ribosome entry site activity.[1]
| Heat shock protein 70 (Hsp70) IRES | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_Hsp70 | |
| Identifiers | |
| Symbol | IRES_Hsp70 |
| Rfam | RF00495 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
References
edit- ^ Rubtsova MP, Sizova DV, Dmitriev SE, Ivanov DS, Prassolov VS, Shatsky IN (June 2003). "Distinctive properties of the 5'-untranslated region of human hsp70 mRNA". The Journal of Biological Chemistry. 278 (25): 22350–22356. doi:10.1074/jbc.M303213200. PMID 12682055.
External links
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