Wikipedia

Helen D. Zepp

Helen Dorothy Zepp (June 28, 1903 – March 18, 1994) was an American medical researcher based in Baltimore and later in New York City. She did research on viruses and vaccines, including polio and herpes.

Helen D. Zepp
A young white woman with bobbed wavy dark hair, in an oval frame
Helen D. Zepp, from the 1927 yearbook of Goucher College
BornJune 28, 1903
Maryland, U.S.
DiedMarch 18, 1994
New York, U.S.
Occupation(s)Medical researcher, bacteriologist

Early life and education

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Zepp was born in Maryland, the daughter of Dorry R. Zepp and Jane (Jennie) Ethel Cridler Zepp.[1] She graduated from Goucher College in 1926.[2]

Career

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Zepp worked at the Philadelphia Hospital for Contagious Diseases after college.[3] She worked at the Harriet Lane Home of Johns Hopkins Hospital, and at Sydenham Hospital in Baltimore, in the 1940s.[4] In 1949, she moved with her collaborator Horace L. Hodes[5] to become assistant to the director of pediatrics at Mount Sinai Hospital in New York City.[6] There, she was part of the team that devised a simple polio immunity test in 1957.[7] "It seems to me that my life is one white mouse after another," she reported to the Goucher alumnae magazine in 1954.[6]

Publications

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Zepp was co-author on articles that appeared in JAMA,[3] Science,[8] Nature,[9] The Journal of Pediatrics,[10] and Experimental Biology and Medicine.[11]

  • "Salmonella Suipestifer Infections in Man" (1933, with Ann G. Kuttner)[3]
  • "Development of antibody following vaccination of infants and children against pneumococci" (1944, with Horace L. Hodes and James F. Ziegler Jr.)[4]
  • "New Method for Detection of Human Poliomyelitis Antibodies" (1957, with Horace L. Hodes, Walter L. Henley, and Ruth Berger)[8]
  • "A Physical Property as a Virus Marker: Difference in Avidity of Cellulose Resin for Virulent (Mahoney) and Attenuated (LSc, 2ab) Strain of Type 1 Poliovirus" (1960, with Horace L. Hodes and Eugene A. Ainbender)[12]
  • "Enhancement of Resistance in Mice to Staphylococcal Infection by Preliminary Treatment with a Staphylococcal Extract" (1961, with Alfred L. Florman, Jeanne L. Scoma, and Eugene Ainbender)[13]
  • "The Difference in Elutability of Poliovirus and SV40 from a DEAE Column" (1962, with Eugene Ainbender and Horace L. Hodes)[14]
  • "Radioautographic Studies of Poliovirus Binding by Human Immunoglobulins" (1965, with Eugene Ainbender, Ruth Berger, M. Magda Hevizy, and Horace L. Hodes)[11]
  • "Study of Viral Antibodies by the Paper-Radioactive Virus Method" (1966, with H. L. Hodes, E. Ainbender, R. Berger, and M. M. Hevizy)[15]
  • "An antibiotic against herpes virus" (1966, with H. L. Hodes, I. H. Leopold, and S. Sherman)[16]
  • "Production of O and H agglutinins by a newborn infant infected with Salmonella st. paul" (1966, with Horace L. Hodes, Eugene Ainbender, Ruth Berger, M. Magda Hevizy)[10]
  • "Demonstration of IgA Polioantibody in Saliva, Duodenal Fluid and Urine" (1967, with Ruth Berger, Eugene Ainbender, Horace L. Hodes, and M. Magda Hevizy)[9]
  • "Human-mosquito somatic cell hybrids induced by ultraviolet-inactivated sendai virus" (1971, with J. H. Conover, K. Hirschhorn, and H. L. Hodes)[17]
  • "Production of human-mosquito somatic cell hybrids and their response to virus infection" (1971, with James H. Conover, Kurt Hirschhorn, and Horace L. Hodes)[18]

References

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  1. ^ "Jennie Ethel Zepp (death notice)". The Baltimore Sun. 1933-06-23. p. 20. Retrieved 2024-10-16 – via Newspapers.com.
  2. ^ Goucher College, Donnybrook Fair (1927 yearbook): 113; via Goucher College Digital Library.
  3. ^ a b c Kuttner, Ann G.; Zepp, H. D. (1933-07-22). "Salmonella Suipestifer Infections in Man". Journal of the American Medical Association. 101 (4): 269. doi:10.1001/jama.1933.02740290017007. ISSN 0002-9955.
  4. ^ a b Hodes, Horace L.; Ziegler, James F.; Zepp, Helen D. (June 1944). "Development of antibody following vaccination of infants and children against pneumococci". The Journal of Pediatrics. 24 (6): 641–649. doi:10.1016/s0022-3476(44)80089-0. ISSN 0022-3476.
  5. ^ Hirschhorn, Kurt (1982). "Presentation of the Howland Award to Horace Louis Hodes, M.D." (PDF). Pediatric Research. 16: 917–919.
  6. ^ a b "Class Notes: 1926". Goucher Alumnae Quarterly. 33 (1): 40. Fall 1954 – via Goucher College Digital Library.
  7. ^ "Simple Polio Immunity Test Devised by Doctors". Fort Worth Star-Telegram. 1957-06-21. p. 44. Retrieved 2024-10-16 – via Newspapers.com.
  8. ^ a b Hodes, Horace L.; Zepp, Helen D.; Henley, Walter L.; Berger, Ruth (1957-05-31). "New Method for Detection of Human Poliomyelitis Antibodies". Science. 125 (3257): 1089–1090. doi:10.1126/science.125.3257.1089. ISSN 0036-8075.
  9. ^ a b Berger, Ruth; Ainbender, Eugene; Hodes, Horace L.; Zepp, Helen D.; Hevizy, M. Magda (April 1967). "Demonstration of IgA Polioantibody in Saliva, Duodenal Fluid and Urine". Nature. 214 (5086): 420–422. doi:10.1038/214420a0. ISSN 1476-4687.
  10. ^ a b Hodes, Horace L.; Zepp, Helen D.; Ainbender, Eugene; Berger, Ruth; Hevizy, Magda (May 1966). "Production of O and H agglutinins by a newborn infant infected with Salmonella st. paul". The Journal of Pediatrics. 68 (5): 780–782. doi:10.1016/s0022-3476(66)80453-5. ISSN 0022-3476.
  11. ^ a b Ainbender, E.; Berger, R.; Hevizy, M. M.; Zepp, H. D.; Hodes, H. L. (1965-08-01). "Radioautographic Studies of Poliovirus Binding by Human Immunoglobulins". Experimental Biology and Medicine. 119 (4): 1166–1169. doi:10.3181/00379727-119-30405. ISSN 1535-3702.
  12. ^ Papers Presented and Discussions Held. Pan american Sanitary Bureau. 1960. pp. 41–43.
  13. ^ Florman, A. L.; Zepp, H.; Ainbender, E.; Scoma, J. L. (1961-08-01). "Enhancement of Resistance in Mice to Staphylococcal Infection by Preliminary Treatment with a Staphylococcal Extract". Experimental Biology and Medicine. 107 (4): 994–997. doi:10.3181/00379727-107-26823. ISSN 1535-3702.
  14. ^ Ainbender, E.; Zepp, H. D.; Hodes, H. L. (1962-06-01). "The Difference in Elutability of Poliovirus and SV40 from a DEAE Column". Experimental Biology and Medicine. 110 (2): 271–273. doi:10.3181/00379727-110-27488. ISSN 1535-3702.
  15. ^ Hodes, Horace L., Ruth Berger, Eugene Ainbender, Helen D. Zepp, and Maria M. Hevizy. "Study of Viral Antibodies by the Paper-Radioactive Virus Method" Pediatrics 37(1)(May 1966): 7-18.
  16. ^ Hodes, Horace L., Helen D. Zepp, Irving H. Leopold, and Spencer Sherman. "An antibiotic against herpes virus." The Journal of Pediatrics 69, no. 5 (1966): 890-891.
  17. ^ Zepp, Helen D.; Conover, James H.; Hirschhorn, Kurt; Hodes, Horace L. (January 1971). "Human–Mosquito Somatic Cell Hybrids induced by Ultraviolet-inactivated Sendai Virus". Nature New Biology. 229 (4): 119–121. doi:10.1038/newbio229119a0. ISSN 0090-0028.
  18. ^ Conover, James H., Helen D. Zepp, Kurt Hirschhorn, and Horace L. Hodes. "Production of human-mosquito somatic cell hybrids and their response to virus infection" in Arthropod Cell Cultures and Their Application to the Study of Viruses, pp. 85-92. Berlin, Heidelberg: Springer Berlin Heidelberg, 1971.
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