Hendryx is a surname. Notable people with the surname include:
- James Hendryx (1880-1963), American author of western fiction
- John Hendryx (born 19?), American theologian (adherent of monergism)
- Nona Hendryx (born 1944), American singer and actress, cousin of Jimi Hendrix
- Tim Hendryx (1891–1957), American baseball player
- JPEGMAFIA (born 1989), American rapper and producer, formerly known as Devon Hendryx