Heparosan-N-sulfate-glucuronate 5-epimerase (EC 5.1.3.17, heparosan epimerase, heparosan-N-sulfate-D-glucuronosyl 5-epimerase, C-5 uronosyl epimerase, polyglucuronate epimerase, D-glucuronyl C-5 epimerase, poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase) is an enzyme with systematic name poly((1->4)-beta-D-glucuronosyl-(1->4)-N-sulfo-alpha-D-glucosaminyl) glucurono-5-epimerase.[1] This enzyme catalyses the following chemical reaction
| Heparosan-N-sulfate-glucuronate 5-epimerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||
| EC no. | 5.1.3.17 | ||||||||
| CAS no. | 112567-86-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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- heparosan-N-sulfate D-glucuronate heparosan-N-sulfate L-iduronate
This enzyme acts on D-glucuronosyl residues adjacent to sulfated D-glucosamine units in the heparin precursor.
See also
editReferences
edit- ^ Bäckström G, Höök M, Lindahl U, Feingold DS, Malmström A, Rodén L, Jacobsson I (April 1979). "Biosynthesis of heparin. Assay and properties of the microsomal uronosyl C-5 epimerase". The Journal of Biological Chemistry. 254 (8): 2975–82. doi:10.1016/S0021-9258(17)30171-0. PMID 107165.
External links
edit- Heparosan-N-sulfate-glucuronate+5-epimerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
