The Hepatitis C virus (HCV) cis-acting replication element (CRE) is an RNA element which is found in the coding region of the RNA-dependent RNA polymerase NS5B. Mutations in this family have been found to cause a blockage in RNA replication and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.[1]
| Hepatitis C virus (HCV) cis-acting replication element (CRE) | |
|---|---|
 Predicted secondary structure and sequence conservation of HepC_CRE | |
| Identifiers | |
| Symbol | HepC_CRE |
| Rfam | RF00260 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | SO:0000233 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ You S, Stump DD, Branch AD, Rice CM (February 2004). "A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication". Journal of Virology. 78 (3): 1352–1366. doi:10.1128/JVI.78.3.1352-1366.2004. PMC 321395. PMID 14722290.
External links
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