HilD 3'UTR regulatory element

The 3′ UTR of mRNA hilD, a master regulator of Salmonella pathogenicity island 1 (SPI-1), is a prokaryotic example of functional 3'UTR. The 3'UTR is a target for hilD mRNA degradation by the degradosome and it may play a role in hilD and SPI-1 expression by serving as a target for the Hfq RNA chaperone. Under non-invasive conditions it is necessary to keep low levels of SPI-1 expression.[1] It plays a role in S. Typhimurium virulence as a regulatory motif.[2]

hilD 3'UTR
Predicted secondary structure and sequence conservation of hilD 3'UTR
Identifiers
RfamRF02689
Other data
Domain(s)Bacteria
GOGO:0030371
SOSO:0005836,SO:0000205
PDB structuresPDBe

References

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  1. ^ López-Garrido J, Puerta-Fernández E, Casadesús J (May 2014). "A eukaryotic-like 3′ untranslated region in Salmonella enterica hilD mRNA". Nucleic Acids Research. 42 (9): 5894–5906. doi:10.1093/nar/gku222. PMC 4027200. PMID 24682814.
  2. ^ Gaviria-Cantin T, El Mouali Y, Le Guyon S, Römling U, Balsalobre C (April 2017). "Gre factors-mediated control of hilD transcription is essential for the invasion of epithelial cells by Salmonella enterica serovar Typhimurium". PLOS Pathogens. 13 (4): e1006312. doi:10.1371/journal.ppat.1006312. PMC 5398713. PMID 28426789.