Holzapfel is a surname. Notable people with the surname include:
- Beate Holzapfel (born 1966), retired West German high jumper
- Brigitte Holzapfel (born 1958), retired West German high jumper
- Hartmut Holzapfel (1944–2022), former Hessian Minister of Culture, Chairman of the Hessian Council on Literature
- James W. Holzapfel (born 1944), American Republican Party politician, served in the New Jersey General Assembly
- Riley Holzapfel (born 1988), Canadian professional ice hockey player
- Rudi Holzapfel (1938–2005), Irish poet and teacher
- Rudolf Maria Holzapfel (1874–1930), Poland-born Austrian psychologist, philosopher