Homoeriodictyol

Homoeriodictyol
Names
	IUPAC name (2S)-4′,5,7-Trihydroxy-3′-methoxyflavan-4-one
	Systematic IUPAC name (2S)-5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
Identifiers
CAS Number	446-71-9 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL490170 ;
ChemSpider	66296 ;
ECHA InfoCard	100.006.523
PubChem CID	73635;
UNII	EHE7H3705C ;
CompTox Dashboard (EPA)	DTXSID30196243 ;
	InChI InChI=1S/C16H14O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-6,13,17-19H,7H2,1H3/t13-/m0/s1 Key: FTODBIPDTXRIGS-ZDUSSCGKSA-N ; InChI=1/C16H14O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-6,13,17-19H,7H2,1H3/t13-/m0/s1 Key: FTODBIPDTXRIGS-ZDUSSCGKBL;
	SMILES COC1=C(C=CC(=C1)[C@@H]2CC(=O)C3=C(C=C(C=C3O2)O)O)O;
Properties
Chemical formula	C16H14O6
Molar mass	302.27876
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Homoeriodictyol is a bitter-masking flavanone extracted from Yerba Santa (Eriodictyon californicum) a plant growing in America.^[1]

Homoeriodictyol (3`-methoxy-4`,5,7-trihydroxyflavanone) is one of the 4 flavanones identified by Symrise in this plant eliciting taste-modifying property: homoeriodictyol sodium salt, eriodictyol and sterubin. Homoeriodictyol Sodium salt elicited the most potent bitter-masking activity by reducing from 10 to 40% the bitterness of salicin, amarogentin, paracetamol and quinine. However no bitter-masking activity was detected with bitter linoleic acid emulsions. According to Symrise's scientists homoeriodictyol sodium salt seems to be a taste-modifier with large potential in food applications and pharmaceuticals.^[2]

Structural relatives investigation based on eriodictyol and homoeriodictyol, found 2,4-Dihydroxybenzoic acid vanillylamide to elicits bitter-masking activity. At 0.1g/L, this vanillin derivative, was able to reduce the bitterness of a 0.5g/L caffeine solution by about 30%.^[3]

References

^ Patricia Kaminski and Richard Katz. Yerba Santa Eriodictyon californicum. Flower Essence Society.
^ Ley JP, Krammer G, Reinders G, Gatfield IL, Bertram HJ (July 2005). "Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae)". J. Agric. Food Chem. 53 (15): 6061–6. doi:10.1021/jf0505170. PMID 16028996.
^ Ley JP, Blings M, Paetz S, Krammer GE, Bertram HJ (November 2006). "New bitter-masking compounds: hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol". J. Agric. Food Chem. 54 (22): 8574–9. doi:10.1021/jf0617061. PMID 17061836.

[1] Patricia Kaminski and Richard Katz. Yerba Santa Eriodictyon californicum. Flower Essence Society.

[2] Ley JP, Krammer G, Reinders G, Gatfield IL, Bertram HJ (July 2005). "Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae)". J. Agric. Food Chem. 53 (15): 6061–6. doi:10.1021/jf0505170. PMID 16028996.

[3] Ley JP, Blings M, Paetz S, Krammer GE, Bertram HJ (November 2006). "New bitter-masking compounds: hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol". J. Agric. Food Chem. 54 (22): 8574–9. doi:10.1021/jf0617061. PMID 17061836.

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