Hosaka (written: 保坂) is a Japanese surname. Notable people with the surname include:
- Choji Hosaka (保坂長治, born 1920), Japanese Olympian and sport shooter
- Edward Yataro Hosaka (1907–1961), American botanist
- Hideki Hosaka (保坂 秀樹, 1971–2021), Japanese professional wrestler
- Kazunari Hosaka (保坂 一成, born 1983), Japanese footballer
- Kazushi Hosaka (保坂 和志, born 1956), Japanese writer
- Kensuke Hosaka (穂坂 健祐), Japanese basketball coach
- Malia Hosaka (born 1969), American professional wrestler
- Nobuto Hosaka (保坂 展人, born 1955), Japanese politician
- Nobuyuki Hosaka (born 1970), Japanese footballer
- Takeshi Hosaka (保坂 武, born 1945), Japanese politician
- Tsukasa Hosaka (保坂 司, 1937–2018), Japanese footballer and manager