Hostetler is a surname of German origin. Notable people with the surname include:
- Abraham J. Hostetler (1818–1899), American politician from Indiana; U.S. representative 1879–81
- Chuck Hostetler (1903–1971), American professional baseball player
- Daniel Hostetler, founder and owner of JetPunk
- Dave Hostetler (b. 1956), American professional baseball player
- David Hostetler (1926–2015), American sculptor
- Jeff Hostetler (b. 1961), American professional football player
- John A. Hostetler (1918–2001), American scholar of the Amish and Hutterite Societies