Hotel Vendome may refer to:
- Hotel Vendome (Prescott, Arizona), a historic hotel on the National Register of Historic Places
- Hotel Vendome (Boston), location of a 1972 fire
- Hotel Vendome in California (see Timeline of San Jose, California)
- Hôtel de Vendôme (boulevard Saint-Michel, Paris), location of the École nationale supérieure des mines de Paris
- Hôtel de Vendôme (place Vendôme, Paris), a hotel since 1858
- Hotel Vendome (novel), a 2011 novel by Danielle Steel