HtrA2 peptidase (EC 3.4.21.108, high temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, serine proteinase OMI, OMI/HtrA2 protease, HtrA2/Omi, Omi/HtrA2) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
| HtrA2 peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.108 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met.
This enzyme is upregulated in mammalian cells in response to stress induced by heat shock and tunicamycin treatment.
References
edit- ^ Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES (August 2003). "Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2". The Journal of Biological Chemistry. 278 (34): 31469–72. doi:10.1074/jbc.C300240200. PMID 12835328.
- ^ Savopoulos JW, Carter PS, Turconi S, Pettman GR, Karran EH, Gray CW, Ward RV, Jenkins O, Creasy CL (July 2000). "Expression, purification, and functional analysis of the human serine protease HtrA2". Protein Expression and Purification. 19 (2): 227–34. doi:10.1006/prep.2000.1240. PMID 10873535.
- ^ Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J (December 2003). "Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi". The Journal of Biological Chemistry. 278 (49): 49417–27. doi:10.1074/jbc.M308659200. PMID 14512424.
- ^ Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL (September 2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". European Journal of Biochemistry. 267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
- ^ Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y (June 2002). "Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi". Nature Structural Biology. 9 (6): 436–41. doi:10.1038/nsb795. PMID 11967569.
External links
edit- HtrA2+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
