Huidobro is a surname. Notable people with the surname include:
- Eleuterio Fernández Huidobro (1942–2016), Uruguayan guerrilla fighter and politician
- Gerardo Huidobro, Peruvian swimmer
- Norma Huidobro
- Pascual Ruiz Huidobro (1752–1813) Spanish colonial governor, active in Montevideo
- Vicente Huidobro (1893–1948), Chilean poet
- Zuleyma Huidobro (born 1978), Mexican politician
- Other uses
- Huidobro, populated place in Burgos Province, Spain
- Villa Huidobro, populated place in Córdoba Province, Argentina