Human lung microvascular endothelial cells (HLMVECs) are cells derived from the pulmonary endothelium. HLMVECs are used as a laboratory model system for the study of the function and pathology of the pulmonary endothelium to research conditions such as ARDS[1] HLMVECs are used due to their simple techniques for isolating them from adult lungs[2] and their ability to easily proliferate in a laboratory setting. When fully confluent they exhibit a cobblestone phenotype just as they do when lining vessel walls.[3]
References
edit- ^ Lazo., Colunga-Biancatelli., Solopov., Catravas. (2023). "An acute respiratory distress syndrome drug development collaboration stimulated by the Virginia Drug Discovery Consortium". SLAS Discovery. 28 (6): 249–254. doi:10.1016/j.slasd.2023.02.001. PMC 9930264. PMID 36796645.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Plebani., D'Alessandro., Lanuti., Simeone., Cinalli., Righi., Palleschi., Mucci., Marchisio., Cappabianca., Camera., Mucilli., Romano. (February 3, 2023). "Microvascular and Macrovascular Endothelial Cell Isolation and Purification from Lung-Derived Samples". JoVE Journal (192). doi:10.3791/64885.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Catravas., Snead., Dimitropoulou., Chang., Lucas., Verin., Black. (2010). "Harvesting, identification and barrier function of human lung microvascular endothelial cells". Vascular Pharmacology. 52 (5–6): 175–81. doi:10.1016/j.vph.2009.12.009. PMC 4374552. PMID 20060932.
{{cite journal}}: CS1 maint: multiple names: authors list (link)