Human rhinovirus internal cis-acting regulatory element (CRE) is a CRE from the human rhinoviruses. The CRE is located within the genome segment encoding the capsid proteins so is found in a protein coding region. The element is essential for efficient viral replication and it has been suggested that the CRE is required for initiation of minus-strand RNA synthesis.[1]
Human rhinovirus internal cis-acting regulatory element (CRE) | |
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![]() Predicted secondary structure and sequence conservation of Rhino_CRE | |
Identifiers | |
Symbol | Rhino_CRE |
Rfam | RF00220 |
Other data | |
RNA type | Cis-reg |
Domain(s) | Viruses |
SO | SO:0000233 |
PDB structures | PDBe |
See also
editReferences
edit- ^ McKnight KL, Lemon SM (December 1998). "The rhinovirus type 14 genome contains an internally located RNA structure that is required for viral replication". RNA. 4 (12): 1569–1584. doi:10.1017/S1355838298981006. PMC 1369726. PMID 9848654.