Huppert is an Ashkenazic surname originating as an Epithet, Byname or Nickname describing personal attributes by combining Old High German (750 to 1050) "Hugh" (meaning “soul”, “mind” or “intellect”) with "beraht" (meaning "bright" or "shining"), given by the community to certain bright-minded individuals. Notable people with the surname include:
- Bertram Huppert (1927–2023), German mathematician
- Boyd Huppert (born 1962), American TV journalist
- Dave Huppert (born 1957), baseball player
- Herbert Huppert (born 1943), geophysicist
- Hugo Huppert (born 1902) Jewish poet, translator and writer
- Isabelle Huppert (born 1953), French actress
- Jennifer Huppert (born 1962), Australian lawyer and politician
- Julian Huppert (born 1978), British scientist and politician