Hydroxyacid oxidase 2

HAO2
Identifiers
Aliases	HAO2, GIG16, HAOX2, hydroxyacid oxidase 2
External IDs	OMIM: 605176; MGI: 96012; HomoloGene: 97412; GeneCards: HAO2; OMA:HAO2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	119,394,130 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	98,800,555 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; testicle; ; renal medulla; ; skin of thigh; ; skin of arm; ; vulva;
	Top expressed in
	left colon; ; adrenal gland; ; proximal tubule; ; human kidney; ; right kidney; ; Gonadal ridge; ; migratory enteric neural crest cell; ; adrenal medulla; ; epithelium of small intestine; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	(S)-2-hydroxy-acid oxidase activity; oxidoreductase activity; FMN binding; signaling receptor binding; catalytic activity;
Cellular component	peroxisome; peroxisomal matrix; cytosol;
Biological process	fatty acid oxidation; fatty acid catabolic process; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
	51179
	56185
	ENSG00000116882
	ENSMUSG00000027870
	Q9NYQ3
	Q9NYQ2
	NM_001005783; NM_016527
	NM_019545
	NP_001005783; NP_057611; NP_001364401
	NP_062418
	Wikidata
View/Edit Human	View/Edit Mouse

Hydroxyacid oxidase 2 is a protein that in humans is encoded by the HAO2 gene. ^[5]

Function

This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116882 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027870 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Hydroxyacid oxidase 2". Retrieved 2016-07-03.

Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N (2010). "Genetic susceptibility to distinct bladder cancer subphenotypes". Eur. Urol. 57 (2): 283–92. doi:10.1016/j.eururo.2009.08.001. PMC 3220186. PMID 19692168.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116882 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027870 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Hydroxyacid oxidase 2". Retrieved 2016-07-03.

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Hydroxyacid oxidase 2

Function

References

Further reading