Bile salt sulfotransferase

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.

SULT2A1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1EFH, 1J99, 1OV4, 2QP3, 2QP4, 3F3Y, 4IFB
Identifiers
Aliases	SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa, sulfotransferase family 2A member 1, DHEA-ST8, SULT2A3
External IDs	OMIM: 125263; MGI: 3645854; HomoloGene: 37741; GeneCards: SULT2A1; OMA:SULT2A1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 47,870,467 bp End 47,886,315 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A1 Start 13,643,601 bp End 13,723,532 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex jejunal mucosa right lobe of liver left adrenal cortex duodenum gonad buccal mucosa cell seminal vesicula cardia mucosa of ileum Top expressed in primary oocyte zygote secondary oocyte spermatocyte spermatid gonad testicle liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity protein binding estrone sulfotransferase activity aryl sulfotransferase activity steroid sulfotransferase activity bile-salt sulfotransferase activity Cellular component cytoplasm cytosol Biological process lipid catabolic process bile acid catabolic process sulfation lipid metabolism ethanol catabolic process regulation of lipid metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process steroid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6822 434121 Ensembl ENSG00000105398 ENSMUSG00000074377 UniProt Q06520 n/a RefSeq (mRNA) NM_003167 NM_001101534 RefSeq (protein) NP_003158 n/a Location (UCSC) Chr 19: 47.87 – 47.89 Mb Chr 7: 13.64 – 13.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.

See also

• Steroid sulfotransferase
• Steroidogenic enzyme

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160. S2CID 12532583.
• Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
• Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
• Kong AN, Yang L, Ma M, et al. (1992). "Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver". Biochem. Biophys. Res. Commun. 187 (1): 448–54. doi:10.1016/S0006-291X(05)81514-1. PMID 1520333.
• Comer KA, Falany CN (1992). "Immunological characterization of dehydroepiandrosterone sulfotransferase from human liver and adrenal". Mol. Pharmacol. 41 (4): 645–51. PMID 1569919.
• Otterness DM, Wieben ED, Wood TC, et al. (1992). "Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA". Mol. Pharmacol. 41 (5): 865–72. PMID 1588921.
• Radominska A, Comer KA, Zimniak P, et al. (1991). "Human liver steroid sulphotransferase sulphates bile acids". Biochem. J. 272 (3): 597–604. doi:10.1042/bj2720597. PMC 1149750. PMID 2268288.
• Forbes KJ, Hagen M, Glatt H, et al. (1995). "Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme". Mol. Cell. Endocrinol. 112 (1): 53–60. doi:10.1016/0303-7207(95)03585-U. PMID 7589785. S2CID 39327051.
• Luu-The V, Dufort I, Paquet N, et al. (1995). "Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene". DNA Cell Biol. 14 (6): 511–8. doi:10.1089/dna.1995.14.511. PMID 7598806.
• Comer KA, Falany JL, Falany CN (1993). "Cloning and expression of human liver dehydroepiandrosterone sulphotransferase". Biochem. J. 289 (1): 233–40. doi:10.1042/bj2890233. PMC 1132155. PMID 7678732.
• Otterness DM, Her C, Aksoy S, et al. (1995). "Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization". DNA Cell Biol. 14 (4): 331–41. doi:10.1089/dna.1995.14.331. PMID 7710689.
• Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM (1995). "Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3". Cytogenet. Cell Genet. 70 (1–2): 45–7. doi:10.1159/000133988. PMID 7736787.
• Falany CN, Wheeler J, Oh TS, Falany JL (1994). "Steroid sulfation by expressed human cytosolic sulfotransferases". J. Steroid Biochem. Mol. Biol. 48 (4): 369–75. doi:10.1016/0960-0760(94)90077-9. PMID 8142314. S2CID 37646598.
• Barker EV, Hume R, Hallas A, Coughtrie WH (1994). "Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes". Endocrinology. 134 (2): 982–9. doi:10.1210/endo.134.2.8299591. PMID 8299591.
• Durocher F, Morissette J, Dufort I, et al. (1996). "Genetic linkage mapping of the dehydroepiandrosterone sulfotransferase (STD) gene on the chromosome 19q13.3 region". Genomics. 29 (3): 781–3. doi:10.1006/geno.1995.9935. PMID 8575776.
• Rubin GL, Harrold AJ, Mills JA, et al. (1999). "Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy". Mol. Hum. Reprod. 5 (11): 995–1002. doi:10.1093/molehr/5.11.995. PMID 10541560.
• Tashiro A, Sasano H, Nishikawa T, et al. (2000). "Expression and activity of dehydroepiandrosterone sulfotransferase in human gastric mucosa". J. Steroid Biochem. Mol. Biol. 72 (3–4): 149–54. doi:10.1016/S0960-0760(00)00020-0. PMID 10775806. S2CID 44681209.
• Pedersen LC, Petrotchenko EV, Negishi M (2000). "Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase". FEBS Lett. 475 (1): 61–4. doi:10.1016/S0014-5793(00)01479-4. PMID 10854859. S2CID 38252369.

External links

• alcohol+sulfotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human SULT2A1 genome location and SULT2A1 gene details page in the UCSC Genome Browser.