Hygromycin B 4-O-kinase (EC 2.7.1.163, hygromycin-B kinase) is an enzyme with systematic name ATP:hygromycin-B 4-O-phosphotransferase.[1] This enzyme catalyses the following chemical reaction
| Hygromycin B 4-O-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.163 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- ATP + hygromycin B ADP + 4-O-phosphohygromycin B
Phosphorylates the antibiotic hygromycin B.
References
edit- ^ Rao RN, Allen NE, Hobbs JN, Alborn WE, Kirst HA, Paschal JW (November 1983). "Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli". Antimicrobial Agents and Chemotherapy. 24 (5): 689–95. doi:10.1128/aac.24.5.689. PMC 185926. PMID 6318654.
External links
edit- Hygromycin+B+4-O-kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
