Hypanis may refer to:
- The Ancient Greek name of the Southern Bug river in Southern Ukraine
- The Ancient Greek name of the Kuban River in Southern Russia
- The Ancient Greek name of the Beas River in the Punjab state of India, also called Hyphasis
- Hypanis (bivalve), a genus of cockles
- Hypanis, an invalid name for a brush-footed butterfly genus, now Byblia