ICI-190,622

ICI-190,622
Clinical data
ATC code	None;
Identifiers
	IUPAC name 4-Amino-1-pent-3-ynyl-N-prop-2-enylpyrazolo[3,4-b]pyridine-5-carboxamide;
CAS Number	103586-12-5 ;
PubChem CID	128415;
ChemSpider	113830 ;
UNII	UC2UD08PKW;
ChEMBL	ChEMBL88106;
CompTox Dashboard (EPA)	DTXSID60145921 ;
Chemical and physical data
Formula	C15H17N5O
Molar mass	283.335 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC#CCCN1C2=NC=C(C(=C2C=N1)N)C(=O)NCC=C;
	InChI InChI=1S/C15H17N5O/c1-3-5-6-8-20-14-11(10-19-20)13(16)12(9-18-14)15(21)17-7-4-2/h4,9-10H,2,6-8H2,1H3,(H2,16,18)(H,17,21) ; Key:ZPOHUNITDKKDQD-UHFFFAOYSA-N ;
	(what is this?) (verify)

ICI-190,622 is an anxiolytic drug used in scientific research. It is a pyrazolopyridine derivative, related to other anxiolytic compounds such as tracazolate, and more distantly to zaleplon. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.^[1]^[2]

References

^ Patel JB, Meiners BA, Salama AI, Malick JB, U'Prichard DC, Giles RE, Goldberg ME, Bare TM (April 1988). "Preclinical studies with pyrazolopyridine non-benzodiazepine anxiolytics: ICI 190,622". Pharmacology Biochemistry and Behavior. 29 (4): 775–9. doi:10.1016/0091-3057(88)90205-5. PMID 2901116. S2CID 23893539.
^ Bare TM, McLaren CD, Campbell JB, Firor JW, Resch JF, Walters CP, Salama AI, Meiners BA, Patel JB (December 1989). "Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents". Journal of Medicinal Chemistry. 32 (12): 2561–73. doi:10.1021/jm00132a011. PMID 2573731.

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[pmid2901116-1] Patel JB, Meiners BA, Salama AI, Malick JB, U'Prichard DC, Giles RE, Goldberg ME, Bare TM (April 1988). "Preclinical studies with pyrazolopyridine non-benzodiazepine anxiolytics: ICI 190,622". Pharmacology Biochemistry and Behavior. 29 (4): 775–9. doi:10.1016/0091-3057(88)90205-5. PMID 2901116. S2CID 23893539.

[pmid2573731-2] Bare TM, McLaren CD, Campbell JB, Firor JW, Resch JF, Walters CP, Salama AI, Meiners BA, Patel JB (December 1989). "Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents". Journal of Medicinal Chemistry. 32 (12): 2561–73. doi:10.1021/jm00132a011. PMID 2573731.

[1]

[2]

Clinical data

ATC code	None
Identifiers
IUPAC name 4-Amino-1-pent-3-ynyl-N-prop-2-enylpyrazolo[3,4-b]pyridine-5-carboxamide
CAS Number	103586-12-5^Y
PubChem CID	128415
ChemSpider	113830^N
UNII	UC2UD08PKW
ChEMBL	ChEMBL88106
CompTox Dashboard (EPA)	DTXSID60145921
Chemical and physical data
Formula	C₁₅H₁₇N₅O
Molar mass	283.335 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC#CCCN1C2=NC=C(C(=C2C=N1)N)C(=O)NCC=C
InChI InChI=1S/C15H17N5O/c1-3-5-6-8-20-14-11(10-19-20)13(16)12(9-18-14)15(21)17-7-4-2/h4,9-10H,2,6-8H2,1H3,(H2,16,18)(H,17,21)^N Key:ZPOHUNITDKKDQD-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

ICI-190,622

See also

References