INO80B (gene)

INO80B
Identifiers
Aliases	INO80B, HMGA1L4, HMGIYL4, IES2, PAP-1BP, PAPA-1, ZNHIT4, hIes2, PAPA1, INO80 complex subunit B
External IDs	OMIM: 616456; MGI: 1917270; HomoloGene: 32566; GeneCards: INO80B; OMA:INO80B - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,457,944 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,102,412 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right uterine tube; ; left ovary; ; pituitary gland; ; fundus; ; anterior pituitary; ; thyroid gland; ; left lobe of thyroid gland; ; right ovary; ; skin of abdomen;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; interventricular septum; ; granulocyte; ; ventricular zone; ; seminiferous tubule; ; muscle of thigh; ; epiblast; ; left lobe of liver; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	nucleus; Ino80 complex; nucleoplasm; nucleolus;
Biological process	chromatin remodeling; DNA recombination; regulation of transcription, DNA-templated; DNA repair; transcription, DNA-templated; cellular response to DNA damage stimulus; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	83444
	70020
	ENSG00000115274
	ENSMUSG00000030034
	Q9C086
	Q99PT3
	NM_031288
	NM_023547
	NP_112578
	NP_076036
	Wikidata
View/Edit Human	View/Edit Mouse

INO80 complex subunit B is a protein that in humans is encoded by the INO80B gene. ^[5]

Function

This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115274 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030034 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: INO80 complex subunit B". Retrieved 2016-12-13.

INO80B (gene)

Function

References

Further reading